2,4-Difluorobenzaldehyde Chemical Properties

Melting point:

2-3 °C (lit.)

Boiling point:

65-66 °C/17 mmHg (lit.)

Density 

1.299 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.498(lit.)

Flash point:

131 °F

storage temp. 

Inert atmosphere,2-8°C

form 

Liquid

Specific Gravity

1.299

color 

Clear colorless

Sensitive 

Air Sensitive

BRN 

2243422

InChI

InChI=1S/C7H4F2O/c8-6-2-1-5(4-10)7(9)3-6/h1-4H

InChIKey

WCGPCBACLBHDCI-UHFFFAOYSA-N

SMILES

C(=O)C1=CC=C(F)C=C1F

CAS DataBase Reference

1550-35-2(CAS DataBase Reference)

NIST Chemistry Reference

2,4-Difluorobenzaldehyde(1550-35-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

10-36/37/38

Safety Statements 

26-36-37/39-16-36/37

RIDADR 

UN 1989 3/PG 3

WGK Germany 

3

F 

10-23

Hazard Note 

Irritant

HazardClass 

3

PackingGroup 

III

HS Code 

29130000

MSDS

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2,4-Difluorobenzaldehyde Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

2,4-Difluorobenzaldehyde was used in the synthesis of 3-benzylidene 20,29-dihydrobetulinic acid derivatives.

General Description

The emission and absorption spectra of 2,4-difluorobenzaldehyde were studied.

Synthesis

(1) Device: Refer to Figure 2 to configure the tubular reactor system. The reactor adopts (3a + 3b) type DC channel and round cake pulse diameter adjustable rectangular flat tube combination design, the specific tube diameter and volume need to be calculated according to the reactant flow and the required residence time to determine, the heat transfer medium selection of heat transfer oil. (2) Preparation of catalyst solution: dissolve 6.06 g of cobalt acetate and 6.06 g of sodium molybdate in 200 mL of 2,4-difluorotoluene and 200 mL of acetic acid, respectively, and mix them well to ensure that n (cobalt acetate): n (2,4-difluorotoluene) = 0.015: 1. Preparation of oxidizer solution: dissolve 6.06 g of sodium bromide in 30% H2O2 to form a solution of H2O2-acetic acid. . Subsequently, 2,4-difluorotoluene-acetic acid solution and H2O2-acetic acid solution were injected into a tubular reactor via a constant flow pump at a flow rate of 5.33 mL/min and 10.67 mL/min, respectively, controlling n(H2O2): n(2,4-difluorotoluene) = 2: 1. The reaction was carried out in a microchannel reactor (shown in Fig. 2) at a temperature maintained at 105 °C and a residence time of 400 s. After completion of the reaction, the outlet material was cooled to 0 °C and quenched with dichloromethane. The conversion of 2,4-difluorotoluene was 49.5% and the yield of 2,4-difluorobenzaldehyde was 31.1% by GC analysis.

References

[1] Patent: CN106588600, 2017, A. Location in patent: Paragraph 0040-0066
[2] Kogyo Kagaku Zasshi, 1956, vol. 59, p. 1160
[3] Chem.Abstr., 1958, p. 13265
[4] Monatshefte fuer Chemie, 1959, vol. 90, p. 683,687
[5] Patent: US5998477, 1999, A

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