Basic information Description References Safety Supplier Related
ChemicalBook >  Product Catalog >  Analytical Chemistry >  Standard >  Pharmaceutical Impurity Reference Standards >  DONEPEZIL HYDROCHLORIDE

DONEPEZIL HYDROCHLORIDE

Basic information Description References Safety Supplier Related

DONEPEZIL HYDROCHLORIDE Basic information

Product Name:
DONEPEZIL HYDROCHLORIDE
Synonyms:
  • AKOS 226-31
  • E-2020
  • DONEPEZIL HCL
  • ARICEPT
  • DonepezilHcl120011-70-3/
  • DONEPEZIL (DONEPEZIL HYDROCHLORIDE)
  • 2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one hydrochloride
  • An oxidized polyethylene wax
CAS:
110119-84-1
MF:
C24H30ClNO3
MW:
415.95
EINECS:
1312995-182-4
Product Categories:
  • API
Mol File:
110119-84-1.mol
More
Less

DONEPEZIL HYDROCHLORIDE Chemical Properties

BCS Class
1
CAS DataBase Reference
110119-84-1(CAS DataBase Reference)
More
Less

DONEPEZIL HYDROCHLORIDE Usage And Synthesis

Description

Donepezil hydrochloride, marketed under the trade name Aricept, is a piperidine-type reversible cholinesterase (ChE) inhibitor, known chemically as (±)-2, 3-dihydro-5, 6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1Hinden- 1-one hydrochloride. It has an empirical formula of C24H29NO3HCl and a molecular weight of 415.96. Donepezil hydrochloride is a white crystalline powder and is freely soluble in chloroform, soluble in water and in glacial acetic acid, slightly soluble in ethanol and in acetonitrile, and practically insoluble in ethyl acetate and in n-hexane. It can bind and reversibly inactivate the cholinesterases, thus inhibiting hydrolysis of acetylcholine. This results in an increased acetylcholine concentration at cholinergic synapses. As for the above function, donepezil hydrochloride can be used for the treatment of symptoms for people with mild-to-severe Alzheimer's disease, but it can’t slow the progression of or cure the disease.

References

1. http://www.rxlist.com/aricept-drug.htm
2. http://www.medbroadcast.com/drug/getdrug/donepezil-hydrochloride
3. http://www.pdr.net/drug-summary/Aricept-donepezil-hydrochloride-138
4. https://en.wikipedia.org/wiki/Donepezil
5. https://www.drugs.com/cdi/donepezil.html

DONEPEZIL HYDROCHLORIDESupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Email
sales.bj@hwrkchemical.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Email
shyysw007@163.com