2-(Hydroxymethyl)pyridine Chemical Properties

Melting point:

5 °C

Boiling point:

112-113 °C/16 mmHg (lit.)

Density 

1.131 g/mL at 25 °C (lit.)

vapor pressure 

3.47Pa at 25℃

refractive index 

n20/D 1.543(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

miscible

form 

Liquid

pka

13.48±0.10(Predicted)

color 

Clear colorless to yellow or brown

Specific Gravity

1.131

PH

6-8 (100g/l, H2O, 20℃)

Odor

pyridine odor

Water Solubility 

miscible

Sensitive 

Hygroscopic

BRN 

107849

InChIKey

SHNUBALDGXWUJI-UHFFFAOYSA-N

LogP

0.11

CAS DataBase Reference

586-98-1(CAS DataBase Reference)

NIST Chemistry Reference

Piconol(586-98-1)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

UT4689000

F 

3-8

Hazard Note 

Irritant/Keep Cold/Hygroscopic

HazardClass 

IRRITANT, HYGROSCOPIC, KEEP COLD

HS Code 

29333999

MSDS

• Language:English Provider:2-(Hydroxymethyl)pyridine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-(Hydroxymethyl)pyridine Usage And Synthesis

Chemical Properties

CLEAR COLORLESS TO YELLOW OR BROWN LIQUID

Uses

decongestant

Uses

A pyridylalcohol with hypoglycemic activity and potential apoptotic effect in human leukemia cells.

Uses

2-Pyridinemethanol is used as a pyridylalcohol with hypoglycemic activity.

Preparation

The preparation of 2-(Hydroxymethyl)pyridine is as follows:NaOH (0.5 g, 12.5 mmol), Al2O3 (2.0 g, 19.6 mmol), aldehyde 1f-g (2 mmol) and H2O (400 μL) were grinded in a mortar. Next, the paste were placed in a glass 10 mL pressure vials and reaction was carried out in microwave reactor: standard mode (200 W), 100 °C, 2 min. After that, reaction mixture was extracted with DCM (2 × 20 mL). Organic layer was evaporated under reduce pressure yielding 2f-g. Solid residue was washed by water (2 × 15 mL). Aqueous phase was acidify with 1N HCl to pH 5.5 and centrifuged. After that aqueous layer was pour down and precipitate was lyophilisated. Products 3f-g were obtained as white solids.

Definition

ChEBI: 2-Pyridinylmethanol is a member of pyridines.

2-(Hydroxymethyl)pyridine(586-98-1)Related Product Information

• 2-Hydroxymethylmorpholine
• 2,4,6-Collidine
• Trimethylolpropane
• Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
• Azamethiphos
• 2,6-Lutidine
• 4-Methylpyridine
• Sulfasalazine
• Pyridine
• 2-Chloro-3-cyanopyridine
• 5-Bromo-2-hydroxymethylpyridine
• 4-Piperidinemethanol
• 3-Aminopyridine
• Chromium picolinate
• 2-Chloro-5-chloromethylpyridine
• Methyl propyl carbonate
• Clopidol
• 2-PYRIDINEMETHANOL HYDROCHLORIDE