Cloquintocet-mexyl Chemical Properties

Melting point:

69°

Boiling point:

448.4±30.0 °C(Predicted)

Density 

1.163±0.06 g/cm3(Predicted)

vapor pressure 

0-54.4Pa at 25-185.9℃

storage temp. 

Sealed in dry,2-8°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)

pka

1.94±0.29(Predicted)

form 

Solid

color 

White to Off-White

Merck 

14,2401

Stability:

Stable. Incompatible with strong oxidizing agents.

LogP

5.2-5.24 at 25℃ and pH5-9.1

Surface tension

56.8-57.2mN/m at 590μg/L and 20℃

Dissociation constant

3.55 at 20℃

CAS DataBase Reference

99607-70-2(CAS DataBase Reference)

EPA Substance Registry System

Cloquintocet-mexyl (99607-70-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

43

Safety Statements 

36/37

RIDADR 

UN 3077

WGK Germany 

2

RTECS 

AG1265000

HS Code 

2933.49.3000

Toxicity

LD50 in rats (mg/kg): >2000 orally; >2000 dermally; LC50 (4 hr) in rats: >935 mg/m3 by inhalation (Amrein)

Cloquintocet-mexyl Usage And Synthesis

Description

Cloquintocet-mexyl is a colourless crystalline herbicide safener. It is categorized as Class III toxin.

Chemical Properties

beige solid

Uses

Cloquintocet-mexyl is used as a herbicide.

Uses

Cloquintocet-mexyl is a herbicide. It is used to control coarse annual grass of the family poaceae (gramineae). lt was developed by the swiss ciba geigy in the 1980s and the patent has expired.

Definition

ChEBI: Heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate is a member of the class of quinolines that is quinoline which is substituted by a chloro group at position 5 and by a 2-[(heptan-2-yl)oxy]-2-oxoethoxy group at position 8. It is an aromatic ether, an organochlorine compound, a member of quinolines and a carboxylic ester.

Agricultural Uses

Cloquintocet-mexyl is a safener that can be used in conjunction with various herbicides to reduce phytotoxicity to crops. Though effective as a safener, the manufacture, storage, and use of cloquintocet-mexyl containing products can present challenges owing to its sensitivity to water and its low melting temperature (i.e., 61-69° C. for technical material). When products containing cloquintocet-mexyl are prepared, stored, or used in the presence of water, cloquin tocet-mexyl can undergo hydrolysis to form cloquintocet acid, and/or form a needle-shaped, crystalline hydrate that can, lead to clogged spray nozzles during spray applications and/or possibly increased levels of crop phytotoxicity.

Carcinogenicity

In accordance with the EPA Proposed EPA Weight-of-the-Evidence Categories, August 1999, the HIARC classified cloquintocet-mexyl as "not likely to be a human carcinogen." Carcinogenicity studies in rats and mice did not show increased incidence of spontaneous tumor formation. With negative mutagenic test battery, it is suggested that cloquintocet-mexyl (CGA 185072) is not likely to be a human carcinogen.

Metabolism

Metabolism studies in rats indicated that approximately 40% of the administered dose of cloquintocet-mexyl was absorbed through the gastrointestinal tract and subsequently excreted via the urine. Fecal excretion accounted for approximately 60% of the administered dose. The chemical was rapidly eliminated (more than 80% of the administered dose) via feces and urine within 48 hours post-dosing. Sex, dosing regime, and dose levels had little effect on the excretion pattern. Excretion patterns were similar between the biliary cannulated and non-cannulated animals indicating that there was no enterohepatic circulation of the chemical. Three days after administration, tissue radioactivity accounted for less than 0.3% of the administered dose (or was non-detectable) and was not detectable in the expired air. At day three post-dosing, most tissue residues of radioactivity were below the limit of detection. The major metabolic pathway of cloquintocet-mexyl was ester hydrolysis to yield 5-chloro-8-quinolinoxy acetic acid, the major metabolite in the fecal and urinary pools.

Toxicity evaluation

Cloquintocet-mexyl has a low order of acute oral, dermal, and inhalation toxicity. It is slightly irritating to the eyes and non-irritating to the skin. Cloquintocet-mexyl is a skin sensitizer. The chemical is not genotoxic and is not a reproductive and developmental toxicant. There is no evidence of neurotoxicity in the available studies. Cloquintocet-mexyl is classified as “not likely to be a human carcinogen.” The main metabolite for cloquintocet-mexyl is 5-chloro-8-quin-linoxyacetic acid, and testing on the metabolite is part of the toxicology database for cloquintocet-mexyl.

Cloquintocet-mexyl(99607-70-2)Related Product Information

• Methyltriethoxysilane
• Isopropyl acetate
• Clioquinol
• Magnesium acetate
• Ethyl acetate
• Butyl acetate
• Ethyl methoxyacetate
• Sodium acetate
• Ethoxyquin
• Cloquintocet
• Methyltrimethoxysilane
• Methoxyacetic acid
• Vinyl acetate
• Ammonium acetate
• Benzyl acetate
• Cellulose acetate
• acetic acid, triethoxy-, ethyl ester
• 4-Methoxyphenylacetic acid