LIDORESTAT
LIDORESTAT Basic information
- Product Name:
- LIDORESTAT
- Synonyms:
-
- LIDORESTAT
- 1H-Indole-1-aceticacid, 3-[(4,5,7-trifluoro-2-benzothiazolyl)methyl]-
- 2-(3-((4,5,7-TRIFLUOROBENZO[D]THIAZOL-2-YL)METHYL)-1H-INDOL-1-YL)ACETIC ACID
- [3-(4,5,7-Trifluorobenzothiazol-2-ylmethyl)indol-1-yl]acetic acid
- 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid
- LIDORESTATUM
- IDD-676
- (VOI)LIDORESTAT
- CAS:
- 245116-90-9
- MF:
- C18H11F3N2O2S
- MW:
- 376.35
- Mol File:
- 245116-90-9.mol
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LIDORESTAT Chemical Properties
- Melting point:
- 177-178℃
- Boiling point:
- 591.4±50.0 °C(Predicted)
- Density
- 1.55
- form
- Solid
- pka
- 4.23±0.10(Predicted)
- color
- Light yellow to yellow
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LIDORESTAT Usage And Synthesis
Uses
Treat ment of diabetic complications, including neuropathy, retinopathy, cataracts, nephropathy (selective aldose reductase inhibitor).
in vivo
Lidorestat (25 mg/kg/day; oral administration; twice daily; for 6 weeks; diabetic mice) treatment decreases fructose and reduces mortality in diabetic hAR-expressing mice. And Lidorestat does not affect weight[1].
| Animal Model: | Diabetic low-density lipoprotein (LDL) receptor-deficient [Ldlr(-/-)] mice[1] |
| Dosage: | 25 mg/kg/day |
| Administration: | Oral administration; twice daily; for 6 weeks |
| Result: | Diabetic hAR-expressing mice had decreased fructose and reduced mortality. |
LIDORESTATSupplier
Cochemical Ltd.
- Tel
- 029-86115547 17791676824
- sales@cochemical.com
Wuxi AppTec
- Tel
- 022-59987777 13552403979
- jia_guoqiang@wuxiapptec.com
Aikon International Limited
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- 025-58859352 18068836627
- dt3@aikonchem.com
3A Chemicals
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- 400-668-9898
- service@3achem.com
Shanghai Jizhi Biochemical Technology Co. Ltd.
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com