3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE Chemical Properties

Density 

2.03±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-1.45±0.30(Predicted)

Appearance

Off-white to light brown Solid

InChI

InChI=1S/C6H3BrClN3/c7-4-3-10-6-5(8)9-1-2-11(4)6/h1-3H

InChIKey

MCEGPQSPRNOFMG-UHFFFAOYSA-N

SMILES

C12=NC=C(Br)N1C=CN=C2Cl

Safety Information

HS Code 

2933998090

3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE Usage And Synthesis

Physical Form

Solid

Synthesis

General procedure for the synthesis of 3-bromo-8-chloroimidazo[1,2-a]pyrazine from 8-chloroimidazo[1,2-a]pyrazine: N-bromosuccinimide (1.78 g, 10 mmol) was added to a solution of 8-chloroimidazo[1,2-a]pyrazine (1.53 g, 10 mmol) in dichloromethane (30 mL), and the reaction was stirred for 2 hours at room temperature. After the reaction was completed, the reaction mixture was washed with saturated aqueous sodium carbonate solution (2×20 mL), dried with anhydrous magnesium sulfate, filtered, and the filtrate was concentrated under reduced pressure to give 3-bromo-8-chloroimidazo[1,2-a]pyrazine (2.11 g, 96% yield).

References

[1] Patent: WO2009/24585, 2009, A2. Location in patent: Page/Page column 46
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 6, p. 1582 - 1585
[3] European Journal of Medicinal Chemistry, 2016, vol. 108, p. 623 - 643
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 17, p. 5170 - 5174
[5] Patent: WO2012/80229, 2012, A1. Location in patent: Page/Page column 40

3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE(143591-61-1)Related Product Information

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