4-METHYLPIPERIDIN-4-OL Chemical Properties

Boiling point:

184.4±15.0 °C(Predicted)

Density 

0.976±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

15.01±0.20(Predicted)

form 

powder

color 

Light Yellow

Safety Information

HS Code 

2933399990

4-METHYLPIPERIDIN-4-OL Usage And Synthesis

Synthesis Reference(s)

Journal of the American Chemical Society, 115, p. 7250, 1993 DOI: 10.1021/ja00069a025

Synthesis

General procedure for the synthesis of 4-methyl-4-hydroxypiperidine from benzyl 4-methylpiperidine-1-carboxylate: the Cbz-protected piperidine derivative mt 3-1 (1.5 g, 6.02 mmol) and Pd/C catalyst (0.3 g) were suspended in methanol (30 mL). The mixture was degassed under reduced pressure and displaced three times with hydrogen. Subsequently, the reaction mixture was stirred overnight at room temperature under hydrogen atmosphere (50 psi). Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to afford the target compound mt 3-2 (500 mg, 72% yield), which was used in subsequent steps without further purification. Mass spectrometric analysis (MS-ES) showed m/z: 116.3 ([M + H]+).

References

[1] Patent: WO2014/197345, 2014, A2. Location in patent: Page/Page column 58; 59
[2] Patent: EP1522540, 2005, A1. Location in patent: Page/Page column 53
[3] Patent: WO2014/194519, 2014, A1. Location in patent: Page/Page column 52

4-METHYLPIPERIDIN-4-OL(3970-68-1)Related Product Information

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