2-AMINO-3'-HYDROXY-ACETOPHENONE HYDROCHLORIDE Chemical Properties

Melting point:

221–222°C

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

Pale Beige to Brown

2-AMINO-3'-HYDROXY-ACETOPHENONE HYDROCHLORIDE Usage And Synthesis

Uses

2-Amino-3’-hydroxy-acetophenone Hydrochloride is a reactant in the synthesis of TRPM8 modulators.

Preparation

Preparation by hydrolysis of m-(benzoyloxy)- a-amino-acetophenone hydrochloride (SM) (m.p. 202–205°) with refluxing 10% hydrochloric acid (quantitative yield), for 2 h (80%); ? with 37% hydrochloric acid in chlorobenzene at 90° for 3 h (90%). SM was obtained by reaction of hexamethylenetetramine with m-(benzoyloxy)- a-bromoacetophenone (m.p. 162°) in ethanol in the presence of 37% hydrochloric acid for 6 h at r.t. (75%).

2-AMINO-3'-HYDROXY-ACETOPHENONE HYDROCHLORIDE(14665-75-9)Related Product Information

• ADRENOCHROME
• rac Benzyl Phenylephrine (Phenylephrine Impurity D)
• (R)-(-)-Phenylephrine-d3 HCl
• benzyl(3-hydroxyphenacyl)methylammonium chloride
• 1,2,3,4-Tetrahydro-4,8-dihydroxy-2-methyl-isoquinoline
• 3-[(1S)-2-[benzyl(methyl)amino]-1-hydroxyethyl]phenol
• Phenylephrine USP RC G
• Phenylephrine EP Impurity D
• Phenylephrine O-Aryl Sulfate
• N-(2-Succinyl) Phenylephrine
• (S)-alpha.-(aminomethyl)-3-hydroxybenzyl alcohol hydrochloride
• 2R,S-HYDROXY-4[[(2R)-2-HYDROXY-2-(3-HYDROXYPHENYL)ETHYL]METHYLAMINO]-4-OXO-BUTANOIC ACID
• 3-Hydroxy-4-[[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]MethylaMino]-4-oxo-butanoic Acid
• N-ACETYL-4-BENZOQUINONE IMINE
• Ethanone, 2,2-dichloro-1-(3-hydroxyphenyl)- (9CI)
• Phenylephrine Impurity 48(Phenylephrine-d3 HCl (Methyl-d3))
• Phenylephrine Impurity 51
• (S)-Phenylephrine hydrochloride