7-Bromo-2-chlorothieno[3,2-d]pyrimidine Chemical Properties

Density 

1.955

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

-0.83±0.40(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2934999090

7-Bromo-2-chlorothieno[3,2-d]pyrimidine Usage And Synthesis

Synthesis

Compound 1-i (CAS: 1293987-55-9, 500 mg, 2.02 mmol) was used as starting material and dissolved in dichloromethane (5 mL). Subsequently, activated manganese dioxide (270 mg, 3.04 mmol) was added to the solution and the reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filter cake was washed with dichloromethane (5 mL, 3 times, 4 mL each). All the filtrates were combined and concentrated under reduced pressure to give a white solid 1-h (430 mg, 86% yield), which was used for subsequent reactions without further purification. The m/z of the product 1-h was measured as m/z = 249 [M + H]+ by LC-MS (ESI) analysis.

References

[1] Patent: EP3287463, 2018, A1. Location in patent: Paragraph 0104; 0106
[2] Patent: WO2011/49332, 2011, A2. Location in patent: Page/Page column 17
[3] Patent: US2012/277424, 2012, A1. Location in patent: Page/Page column 8
[4] Patent: US2018/208604, 2018, A1. Location in patent: Paragraph 0368-0369

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