4-Amino-2-fluoro-5-methoxybenzoic acid Chemical Properties

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

Appearance

Light yellow to brown Solid

InChI

InChI=1S/C8H8FNO3/c1-13-7-2-4(8(11)12)5(9)3-6(7)10/h2-3H,10H2,1H3,(H,11,12)

InChIKey

AOFWIQANMFITAG-UHFFFAOYSA-N

SMILES

C(O)(=O)C1=CC(OC)=C(N)C=C1F

Safety Information

HS Code 

2922500090

4-Amino-2-fluoro-5-methoxybenzoic acid Usage And Synthesis

Synthesis

A solution of 2-fluoro-5-methoxy- 4-nitrobenzoic acid (10 g, 46 mmol), HOAc (50 mL), and MeOH (50 mL) was hydrogenated using a hydrogen balloon overnight. The solution was then filtered through celite and concentrated to a residue, which was triturated with ether and ethyl acetate. The solid was filtered and dried to give the product 4-Amino-2-fluoro-5-methoxybenzoic acid as a light yellow powder (8.3 g, 98 %).

References

[1] Patent: WO2009/42711, 2009, A1. Location in patent: Page/Page column 266
[2] Patent: US2008/9482, 2008, A1. Location in patent: Page/Page column 134
[3] Patent: WO2008/40951, 2008, A1. Location in patent: Page/Page column 150
[4] Patent: WO2008/40951, 2008, A1. Location in patent: Page/Page column 150
[5] Patent: WO2009/42711, 2009, A1. Location in patent: Page/Page column 387-388

4-Amino-2-fluoro-5-methoxybenzoic acid(1001346-91-3)Related Product Information

• Hexyl benzoate