ChemicalBook > Product Catalog > Pharmaceutical intermediates > Bulk Drug Intermediates > 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Basic information
- Product Name:
- 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
- Synonyms:
-
- 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
- Tolvaptan InterMediates
- 7-chloro-1-(2-Methyl-4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
- 1H-benzo[b]azepine
- 7-Chloro-1,2,3,4-Tetrahydro-1-(2-Methyl-4-Nitrobenzoyl)-5H-1-Benzazepine-5-One
- Tolvaptan Impurity 12
- 7-chloro-1-(2-methyl-4-nitrobenzoyl)-3,4-dihydro-2H-1-benzazepin-5-one
- 7-chloro-1-(2-methyl-4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
- CAS:
- 137982-91-3
- MF:
- C18H15ClN2O4
- MW:
- 358.78
- EINECS:
- 1592732-453-0
- Product Categories:
-
- Pharmaceutical Intermediates
- Mol File:
- 137982-91-3.mol
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7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Chemical Properties
- Melting point:
- 152 - 155°C
- Boiling point:
- 573.3±50.0 °C(Predicted)
- Density
- 1.387
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -2.58±0.20(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C18H15ClN2O4/c1-11-9-13(21(24)25)5-6-14(11)18(23)20-8-2-3-17(22)15-10-12(19)4-7-16(15)20/h4-7,9-10H,2-3,8H2,1H3
- InChIKey
- NNCRQBJNAGEBDM-UHFFFAOYSA-N
- SMILES
- N1(C(=O)C2=CC=C([N+]([O-])=O)C=C2C)C2=CC=C(Cl)C=C2C(=O)CCC1
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7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Usage And Synthesis
Uses
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one is an intermediate in synthesizing Tolvaptan-d7 (T536652), a labelled Tolvaptan (T536650). It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-oneSupplier
Enki Biopharmaceuticals(Shanghai) Limited Gold
- Tel
- 021-57680965 13916707528
- yusu@enkibiopharma.com
Jiangxi Jinfeng Pharmaceutical Co., Ltd Gold
- Tel
- 793-5181188 18170363299
- yangyuening@jxjfpharma.com
Suzhou Junye Biopharmaceutical Technology Co., Ltd Gold
- Tel
- 0512-53662086-8001 18913766772
- wangli@jyk-biotech.com
Chembest Research Laboratories Limited
- Tel
- 021-20908456
- sales@BioChemBest.com
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
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7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one(137982-91-3)Related Product Information
- Ethyl 7-Chloro-5-oxo-1-toxyl-2,3,4,5,-tetrahydro-1H-benzo[b]azepine-4-carboxylate
- Tolvaptan Impurity 18
- Tolvaptan Impurity 13
- 5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester
- Tolvaptan Impurity 21
- Tolvaptan Impurity 3 (DM-4104)
- Tolvaptan Impurity 30
- 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one
- Tolvaptan Impurity 17
- Tolvaptan impurity 2
- Tolvaptan Impurity 20
- Tolvaptan Impurity 15
- Tolvaptan Impurity 11
- Tolvaptan Impurity 26
- Tolvaptan
- 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one
- 5-Dehydro Tolvaptan
- 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one