ChemicalBook > Product Catalog > Organic Chemistry > Organic fluorine compound > 2-(3,4-Dichlorophenyl)-4-fluoroaniline
2-(3,4-Dichlorophenyl)-4-fluoroaniline
2-(3,4-Dichlorophenyl)-4-fluoroaniline Basic information
- Product Name:
- 2-(3,4-Dichlorophenyl)-4-fluoroaniline
- Synonyms:
-
- 3',4'-dichloro-5-fluoro-[1,1'-biphenyl]-2-aMine
- [1,1']-biphenyl-2-aMine-3',4'-dichloro-5-fluoro
- 2-(3,4-Dichlorophenyl)-4-fluoroaniline
- 3',4'-Dichloro-5-fluorobiphenyl-2-amine
- 2-amino-5-fluoro-3,4-dichlorobenzene
- 2- amino -5- fluoro -3',4'- dichlorobiphenyl
- 3',4'-Dichloro-5-fluoro-[1,1'-biphenyl]-2-amine
- 2- amino -5- fluoro -3',4'- dichlorobiphenyl
- CAS:
- 877179-04-9
- MF:
- C12H8Cl2FN
- MW:
- 256.1
- EINECS:
- 700-287-9
- Mol File:
- 877179-04-9.mol
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2-(3,4-Dichlorophenyl)-4-fluoroaniline Chemical Properties
- Boiling point:
- 357℃ at 101.3kPa
- Density
- 1.47 at 20℃
- storage temp.
- 2-8°C
- pka
- 3.22±0.10(Predicted)
- LogP
- 4.3 at 22℃ and pH7
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2-(3,4-Dichlorophenyl)-4-fluoroaniline Usage And Synthesis
Synthesis
8.15 g (97%, 0.042 mol) of 3,4-dichlorophenylboronic acid are initially charged in 50 g of water and 50 g toluene. Subsequently, 18.7 g (0.085 mol) of potassium phosphate and 8.2 g (98%, 0.042 mol) of 2-bromo-4-fluoroaniline are added. After blanketing with nitrogen, 0.014 g (0.00002 mol) of 1,1'-bis(di-test-butyl phosphine) ferrocene palladium dichloride is added, and the mixture is stirred for two hours at 79-81° C. The organic phase is separated and evaporated under reduced pressure, leaving 10.5 g of an oil-crystallized 2-(3,4-Dichlorophenyl)-4-fluoroaniline.
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