5,6-difluoro-indoline-2,3-dione Chemical Properties

Melting point:

218-220℃

Density 

1.578±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

7.32±0.20(Predicted)

form 

solid

color 

Orange

Safety Information

HS Code 

2933998090

5,6-difluoro-indoline-2,3-dione Usage And Synthesis

Synthesis

GENERAL PROCEDURE: To a stirred 18.1 M aqueous sulfuric acid solution (0.68 mL/mmol), isonitrosoacetanilide (1 equiv.) was added in batches at 60 °C. The reaction mixture was placed in a heating block and stirred at an internal temperature of 80 °C for 30 min, followed by cooling to room temperature. The reaction solution was slowly poured into a saturated ice-water mixture (5 mL/g) and stirred at room temperature for 10 minutes. The resulting solid was collected by filtration, dried and purified according to standard methods.

References

[1] Synlett, 2016, vol. 27, # 10, p. 1516 - 1520
[2] Journal of Organic Chemistry, 1958, vol. 23, p. 1858,1860