Amifostine Thiol Dihydrochloride Chemical Properties

Melting point:

184-186°C

storage temp. 

-20°C

solubility 

H2O: ≥20mg/mL

form 

powder

color 

white to off-white

Stability:

Hygroscopic

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-41

Safety Statements 

26-39-41

WGK Germany 

3

HS Code 

2930909165

Toxicity

mouse,LD50,intraperitoneal,400mg/kg (400mg/kg),European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 24, Pg. 48, 1989.

Amifostine Thiol Dihydrochloride Usage And Synthesis

Chemical Properties

White Solid

Uses

A metabolite of Amifostine.

Biochem/physiol Actions

WR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy.

storage

Desiccate at -20°C

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