Amifostine Thiol Dihydrochloride
Amifostine Thiol Dihydrochloride Basic information
- Product Name:
- Amifostine Thiol Dihydrochloride
- Synonyms:
-
- Amifostine Thiol Dihydrochloride
- 2-[(3-Aminopropyl)amino]ethanethioldihydrochloride
- Amifostine Thiol (50 mg) (2-[(3-aminopropyl)amino]ethanethiol, dihydrochloride)
- AMifostine Thiol
- 2-[(3-AMinopropyl)aMino]ethanethiol Hydrochloride
- WR-1065 dihydrochloride
- WR-1065 2HCl
- Amifostine Thiol Dihydrochloride (90%)
- CAS:
- 14653-77-1
- MF:
- C5H14N2S
- MW:
- 134.24306
- Product Categories:
-
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Mol File:
- 14653-77-1.mol
Amifostine Thiol Dihydrochloride Chemical Properties
- Melting point:
- 184-186°C
- storage temp.
- -20°C
- solubility
- H2O: ≥20mg/mL
- form
- powder
- color
- white to off-white
- Water Solubility
- H2O: ≥20mg/mL
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C5H14N2S/c6-2-1-3-7-4-5-8/h7-8H,1-6H2
- InChIKey
- YHPLKWQJMAYFCN-UHFFFAOYSA-N
- SMILES
- NCCCNCCS
Amifostine Thiol Dihydrochloride Usage And Synthesis
Chemical Properties
White Solid
Uses
A metabolite of Amifostine.
Biochem/physiol Actions
WR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy.
in vivo
The results show that Amifostine thiol dihydrochloride (Amifostine thiol) attenuates the severity of 6-OHDA-induced catalepsy (P<0.001) when compare with 6-OHDA-lesioned rats. Also it has been observed that Amifostine thiol dihydrochloride improves catalepsy in dose dependent manner (P<0.001). Pretreatment with three different doses of Amifostine thiol dihydrochloride (20, 40 and 80 μg/2 μL/rat) for 3 days before 6-OHDA administration, significantly (P<0.001) elevates SOD activity and restores it to normal range compare with 6-OHDA lesioned rats[3].
storage
Desiccate at -20°C
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