Di(N-succinimidyl) adipate Chemical Properties

Melting point:

163-164℃ (ethanol acetonitrile )

Boiling point:

495.3±55.0 °C(Predicted)

Density 

1.48±0.1 g/cm3 (20 ºC 760 Torr)

storage temp. 

Storage temp. -20°C

solubility 

Soluble in DMSO, DMF, Acetonitrile

form 

Solid

color 

White to off-white

InChI

InChI=1S/C14H16N2O8/c17-9-5-6-10(18)15(9)23-13(21)3-1-2-4-14(22)24-16-11(19)7-8-12(16)20/h1-8H2

InChIKey

LZZXZDMVRZJZST-UHFFFAOYSA-N

SMILES

C(ON1C(=O)CCC1=O)(=O)CCCCC(ON1C(=O)CCC1=O)=O

Di(N-succinimidyl) adipate Usage And Synthesis

Description

Di(N-succinimidyl)adipate contains two NHS ester groups which can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Uses

Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

Alkyl-Chain

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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