Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate Chemical Properties

Boiling point:

349.0±44.0 °C(Predicted)

Density 

1.23

vapor pressure 

0.008Pa at 25℃

pka

11.63±0.10(Predicted)

InChI

InChI=1S/C11H13ClN2O3/c1-3-17-11(15)10(12)14-13-8-4-6-9(16-2)7-5-8/h4-7,13H,3H2,1-2H3/b14-10-

InChIKey

ATNPZEGMKLGIFA-UVTDQMKNSA-N

SMILES

C(OCC)(=O)/C(/Cl)=N/NC1=CC=C(OC)C=C1

LogP

2.53

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate Usage And Synthesis

Uses

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical and pharmaceutical production processes.

Synthesis

Preparation of ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate To p-anisidine (16 g, 0.129 mol) in conc. HCL (40 mL), 100 mL) H2O, cooled to -5?? C. and sodium nitrite (9.4 g, 0.136 mol) in H2O (60 mL) was added. The reaction mixture was stirred at -5?? C. for 20 min and a mixture of ethylchloroacetoacetate (22 g, 0.133 mol), ethanol (100 mL), sodiumacetate (32 g, 0.389 mmol), and H2O (400 mL) was added. The reaction was allowed to warm up to room temperature and stirred for 2h. The product precipitated as a black solid. It was filtered and dried (30 g). 1H-NMR (CDCl3) |? 8.28 (s, 1H), 7.18 (d, 2H), 6.90 (d, 2H), 4.41 (q, 2H), 3.80 (s, 3H), 1.42 (t, 3H) ppm.

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate(473927-63-8)Related Product Information

• Apixaban IMpurity 2
• 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
• 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
• ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
• ETHYL (2E)-CHLORO[(4-CHLOROPHENYL)HYDRAZONO]ACETATE
• 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
• 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide
• 1-(4-(2-methyl-6-oxopiperidin-1-yl)phenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
• 1-(4-Hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
• 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE
• ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
• Apixaban IMpurity(BMS-591329-01)
• 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
• Apixaban Impurity 16
• Apixaban Impurity 13
• 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
• 1-(4-Nitrophenyl)-2-piperidinone
• Apixaban