Methyl 2-chlorobenzoate Chemical Properties

Melting point:

233-235 °C

Boiling point:

233-235 °C

Density 

1.191 g/mL at 25 °C(lit.)

refractive index 

1.5351-1.537

Flash point:

108 °C

storage temp. 

Store below +30°C.

form 

Liquid

Specific Gravity

1.191

color 

Clear colorless

BRN 

1364684

InChI

InChI=1S/C8H7ClO2/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5H,1H3

InChIKey

JAVRNIFMYIJXIE-UHFFFAOYSA-N

SMILES

C(OC)(=O)C1=CC=CC=C1Cl

CAS DataBase Reference

610-96-8(CAS DataBase Reference)

NIST Chemistry Reference

6-Chlorobenzoic acid, methyl ester(610-96-8)

EPA Substance Registry System

Methyl-2-chlorobenzoate (610-96-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25

WGK Germany 

3

TSCA 

TSCA listed

HazardClass 

IRRITANT

HS Code 

29163990

Storage Class

10 - Combustible liquids

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

Methyl 2-chlorobenzoate Usage And Synthesis

Chemical Properties

White to light yellow crystal powder

Uses

Methyl 2-chlorobenzoate may be used in the synthesis of various quinazolinone derivatives. It was used as starting reagent in the synthesis of 2-chlorobenzohydrazide.

General Description

Methyl 2-chlorobenzoate, a methyl 2-halobenzoate, is an ester. It can be synthesized from 2-chlorobenzoyl chloride. Its reduction with NaBH₄ in diglyme at 162°C affords 2-chlorobenzyl alcohol.

Synthesis

Report I.

Magnets, 1 mmol 1-chloro-2-(methoxymethyl)benzene (170 mg), 20 mg20 mol% AgI/BiVO4 composite and 2 mL ethanol were sequentially added to a 25 mL reaction vial, equipped with a 28 cm diameter oxygen sphere, and a 16 W white-light lamp was equipped at the right side of the vial at a distance of 10 cm, the reaction system The reaction system was reacted under the irradiation of a 16 W white light lamp for 16 h. The reaction solution was extracted, and the combined organic layers were washed three times with saturated brine, dried with anhydrous sodium sulfate, desolvated under reduced pressure, and the residue was processed by column chromatography (ethyl acetate/petroleum ether=1:10) to obtain methyl phthalate in 71% yield (120.4 mg).

Report II,

20 mg Au-Co composite particle loadings (0.1 mol%), 13.8 mg K2CO3 (10 mol%), 142.5 mg o-chlorobenzoic acid methanol (lmmol), and 4 mL of methanol were added sequentially to a pressure kettle with a 25 mL glass liner, and the oxygen was replaced three times and then the pressure was filled up to 0.l MPa. 80 ?? reaction 10h, cooled to room temperature, slowly bleed down the pressure, filtration of catalyst, filtrate spin concentration, residue column chromatography to get a yellowish liquid product methyl phlorobenzoate 159.6mg, yield 90%.

Methyl 2-chlorobenzoate (610-96-8)Related Product Information

• METHYL THIOPHENE-2-CARBOXYLATE
• Methyl formate
• Trimethoxymethane
• Bensulfuron methyl
• 2-Chlorobenzaldehyde
• Methyl 3,5-dihydroxybenzoate
• 2-Chlorophenylacetic acid
• Methyl acetate
• Methyl acrylate
• 2-Chlorophenol
• Methylparaben
• 2-Chlorobenzoic acid
• Methyl anthranilate
• Kresoxim-methyl
• Methyl 2-bromobenzoate
• Methyl benzoate
• Thiophanate-methyl
• Methyl