(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Chemical Properties

storage temp. 

desiccated

solubility 

DMSO : 25 mg/mL (79.65 mM; Need ultrasonic)H2O : 12.5 mg/mL (39.83 mM; Need ultrasonic)

form 

powder

color 

white

Safety Information

WGK Germany 

3

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Usage And Synthesis

Description

ICI 118551 is a potent, selective antagonist of the β₂-adrenergic receptor (K_i = 0.7 nM for the β₂receptor, compared with 49.5 and 611 nM for β₁ and β₃ receptors, respectively). It is active in vivo and is often used to evaluate the actions of adrenergic receptor agonists.

Uses

ICI 118,551 hydrochloride has been used:

• to block β-adrenergic signaling in various experiments
• to counteract degradation by endogenous T-lymphocyte monoamine oxidases
• to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts

Uses

The (R,R)-enantiomer of ICI 118551 as highly selective β2-adrenoceptor antagonist. The S,S-enantiomer is the most potent.

Biochem/physiol Actions

ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.

storage

Store at RT

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