4,5-Dimethoxycanthin-6-one Chemical Properties

Melting point:

145-146 °C

Boiling point:

455.1±45.0 °C(Predicted)

Density 

1.40±0.1 g/cm3(Predicted)

pka

3.51±0.20(Predicted)

form 

Solid

color 

Light yellow to yellow

4,5-Dimethoxycanthin-6-one Usage And Synthesis

Uses

4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae)[1][2].

Definition

ChEBI: Methyl nigakinone is a member of beta-carbolines.

IC 50

CYP1A2: 1.7 μM (IC₅₀); CYP1A2: 2.6 μM (Ki)

References

[1] Taichi O, et al. Studies on the Constituents of Picrasma quassioides BENNET. III. The Alkaloidal Constituents
[2] Miao X,et al. In vitro metabolism of 4, 5-dimethoxycanthin-6-one by human liver microsomes and its inhibition on human CYP1A2. Life Sci. 2017;190:46-51. DOI:10.1016/j.lfs.2017.09.031

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