Kongensin A Chemical Properties

Melting point:

160-162 °C(Solv: chloroform (67-66-3))

Boiling point:

525.7±50.0 °C(Predicted)

Density 

1.17±0.1 g/cm3(Predicted)

storage temp. 

4°C, protect from light

form 

Solid

pka

13.07±0.70(Predicted)

color 

White to light yellow

Kongensin A Usage And Synthesis

Uses

Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications[1].

References

[1] Li D, et al. Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis. Cell Chem Biol. 2016 Feb 18;23(2):257-266. DOI:10.1016/j.chembiol.2015.08.018

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