Ethanol, 2-[2-(2-bromoethoxy)ethoxy]- Chemical Properties

Boiling point:

276.3±20.0 °C(Predicted)

Density 

1.411±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in Water, DMSO, DMF, DCM

pka

14.36±0.10(Predicted)

form 

Liquid

color 

Light yellow to yellow

InChI

InChI=1S/C6H13BrO3/c7-1-3-9-5-6-10-4-2-8/h8H,1-6H2

InChIKey

JYRDRGOLCZHQJZ-UHFFFAOYSA-N

SMILES

C(O)COCCOCCBr

Ethanol, 2-[2-(2-bromoethoxy)ethoxy]- Usage And Synthesis

Description

Bromo-PEG3-alcohol is a PEG linker containing a bromide group with a terminal hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

Br-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Ethanol, 2-[2-(2-bromoethoxy)ethoxy]-(57641-67-5)Related Product Information

• Cyclopropyl bromide
• 2-Bromomethyl-1,3-dioxolane
• Bromo-PEG4-acid
• Bromo-PEG4-t-butyl ester
• Bromo-PEG6-alcohol
• 3,6,9,12-Tetraoxatetradecan-1-ol, 14-bromo-
• Bromo-PEG8-t-butyl ester
• Bromo-PEG2-acid
• Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-
• Ethanol, 2-(2-bromoethoxy)-