Basic information Safety Supplier Related

Zonisamide sodium salt

Basic information Safety Supplier Related

Zonisamide sodium salt Basic information

Product Name:
Zonisamide sodium salt
Synonyms:
  • ZON
  • 1,2-BENZISOXAZOLE-3-METHANESULFONAMIDE
  • BENZO[D]ISOXAZOL-3-YL-METHANESULFONAMIDE
  • 1,2-benzisoxazole-3-methanesulfonamide sodium-potassium salt
  • 1,2-Benzisoxazole-3-methanesulfonamide sodium-potassium salt, Aleviatin sodium-potassium salt, Exceglan sodium-potassium salt, Excegram sodium-potassium salt
  • 1,2-Benzisoxazole-3-methanesulfonamide sodium salt
  • Zonisamide sodium salt
  • ZonisaMide (sodiuM)
CAS:
68291-98-5
MF:
C8H7N2NaO3S
MW:
234.21
Mol File:
68291-98-5.mol
More
Less

Zonisamide sodium salt Chemical Properties

storage temp. 
Store at -20°C
solubility 
H2O: >5mg/mL
form 
powder
color 
white to beige
Water Solubility 
H2O: >5mg/mL
More
Less

Safety Information

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
More
Less

Zonisamide sodium salt Usage And Synthesis

Uses

Zonisamide Sodium Salt can be used in biological study of neuroprotective effects of zonisamide target astrocyte. It shows neuroprotection by increasing glutathione, cystine/glutamate exchange transporter expression in mouse CNS catecholaminergic, astrocyte and rat glioma cell and mouse model of 6-OHDA induced hemi-Parkinson''s disease

Biochem/physiol Actions

Zonisamide sodium salt is an anti-epileptic. It is effective in various animal epilepsy models and humans with both partial and generalized epileptic seizures. Zonisamide sodium salt also scavenges nitric oxide (NO).

in vivo

Zonisamide sodium (40 mg/kg; i.p.; single daily for 14 days) prevents seizures in FeCl3-induced chronic amygdalar seizures model[2].
Zonisamide sodium (14, 28, 56 mg/kg; i.p.; single daily for 6 weeks) alleviates cardiac hypertrophy and improved cardiac function in rats subjected to AAC (abdominal aortic constriction)[3].
Zonisamide sodium (14, 28, 56 mg/kg; i.p.; single daily for 6 weeks) upregulates Hrd1 expression and accelerates ERAD in the hearts of AAC rats[3].

Animal Model:Male Wistar rats (200-250 g; FeCl3-induced chronic amygdalar seizures)[2].
Dosage:40 mg/kg
Administration:Intraperitoneal injection; single daily for 14 days.
Result:Showed activity of anti-seizures.
Significantly down-regulated GABA transporters GAT-1 in the hippocampus.
Animal Model:Adult male Sprague-Dawley rats (100-120 g; cardiac hypertrophy model)[3].
Dosage:14, 28, 56 mg/kg (dissolved in 1% DMSO)
Administration:Intraperitoneal injection; single daily for 6 weeks.
Result:Significantly attenuated cardiac hypertrophy and fibrosis.
Increased LV ejection fraction (EF), fractional shortening (FS) and E/A ratio.
Markedly increased the expression of Hrd1 in the hearts of AAC rats.

Zonisamide sodium saltSupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Email
Sales@ATKchemical.com
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Email
2885676761@qq.com
More
Less

Zonisamide sodium salt(68291-98-5)Related Product Information