2'-Hydroxy-4'-methylacetophenone Chemical Properties

Melting point:

21°C

Boiling point:

245 °C(lit.)

Density 

1.08 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.565(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

form 

clear liquid

pka

10.27±0.10(Predicted)

color 

Colorless to Light orange to Yellow

λmax

325nm(MeOH)(lit.)

InChIKey

LYKDOWJROLHYOT-UHFFFAOYSA-N

CAS DataBase Reference

6921-64-8(CAS DataBase Reference)

EPA Substance Registry System

Ethanone, 1-(2-hydroxy-4-methylphenyl)- (6921-64-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

HS Code 

2914500090

MSDS

• Language:English Provider:SigmaAldrich

2'-Hydroxy-4'-methylacetophenone Usage And Synthesis

Uses

2′-Hydroxy-4′-methylacetophenone is found in Angelica koreana roots and a study was done in which it could be useful for natural acaricides against three mite species.

Preparation

Preparation by treatment of methyl 4-hydroxy-7- methyl-coumarin-3-carboxylate with potassium hydroxide at 200° (87%).

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 4183, 1996 DOI: 10.1016/0040-4039(96)00790-3

General Description

2′-Hydroxy-4′-methylacetophenone, also known as 1-(2-hydroxy-4-methylphenyl)ethanone can be synthesized by the Fries rearrangement of m-tolyl acetate in the presence of zirconium tetrachloride. The results from the toxicity studies on mite species suggest that 2′-hydroxy-4′-methylacetophenone possesses acaricidal property.

2'-Hydroxy-4'-methylacetophenone(6921-64-8)Related Product Information

• 2'-Methylacetophenone
• 4-Nitroacetophenone
• 4'-(Trifluoromethyl)acetophenone
• 4'-Hydroxyacetophenone
• CHLOROPHOSPHONAZO III
• PIPERACETAZINE (250 MG)
• 3'-Methylacetophenone
• 3-Nitroacetophenone
• 4'-Methylacetophenone
• 2'-Hydroxyacetophenone
• 3'-(Trifluoromethyl)acetophenone
• Acetophenone
• 4'-Methoxyacetophenone
• 2',4'-Dichloroacetophenone
• FRANGULIN B
• Chrysophanic acid
• 5-CHLORO-2-HYDROXY-4-METHYLBENZOPHENONE
• Emodin