5-Aminofluorescein
5-Aminofluorescein Basic information
- Product Name:
- 5-Aminofluorescein
- Synonyms:
-
- 5-Amino-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one Fluoresceinamine
- 5-amino-3',6'-dihydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one
- FLUORESCEINAMINE
- FLUORESCEINAMINE ISOMER I
- FLUORESCEINAMINE, ISOMER 1
- 5-amino-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
- 5-AMINO-3',6'-DIHYDROXYSPIRO[ISOBENZOFURAN-1(3H),9'-(9H)XANTHEN]-3-ONE
- 5-AMINOFLUORESCEIN ISOMER I
- CAS:
- 3326-34-9
- MF:
- C20H13NO5
- MW:
- 347.32
- EINECS:
- 222-043-6
- Product Categories:
-
- marker
- Fluorescent Labels and Indicators
- Fluorescent Labels & Indicators
- Mol File:
- 3326-34-9.mol
5-Aminofluorescein Chemical Properties
- Melting point:
- 223 °C (dec.)(lit.)
- Boiling point:
- 481.89°C (rough estimate)
- Density
- 1.3724 (rough estimate)
- refractive index
- 1.5180 (estimate)
- storage temp.
- room temp
- solubility
- DMF: 5 mg/ml; DMSO: 5 mg/ml
- pka
- 9.34±0.20(Predicted)
- form
- powder
- color
- red-brown
- Water Solubility
- Soluble in water (partly), methanol (10 mg/ml), and acetone.
- BRN
- 48395
- Stability:
- Light and Moisture Sensitive
- InChIKey
- GZAJOEGTZDUSKS-UHFFFAOYSA-N
- CAS DataBase Reference
- 3326-34-9(CAS DataBase Reference)
- EPA Substance Registry System
- Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5-amino-3',6'-dihydroxy- (3326-34-9)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
- F
- 10
- TSCA
- Yes
- HS Code
- 32049090
MSDS
- Language:English Provider:5-Amino-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
5-Aminofluorescein Usage And Synthesis
Chemical Properties
Dark Red Solid
Uses
Glycosaminoglycuronans react with 5-aminofluorescein to yield fluorescent derivatives. 5-aminofluorescein is also used to prepare FITC Isomer I (F-011, F-020).
Uses
5-aminofluorescein is also used to prepare FITC Isomer I (CDX-F0011, CDX-F0020). It is a chemical used as molecular probe and important as fluorescent dye and for derivatives. Fluorescent labeling reagent for proteins. Used in the fluorescent antibody technique for rapid identification of pathogens.
Definition
ChEBI: 5-aminofluorescein is a primary amino compound that is fluorescein carrying an amino substituent at C-5. Building block/intermediate for the synthesis of the fluorescent dye flourescein; also used to produce N-(fluorescein-5-yl)maleamic acid. It derives from a fluorescein (lactone form).
Preparation
The preparation of 5-aminofluorescein is carried out either by first saponification of 5-nitrofluorescein acetates with alcohol alkali, followed by reduction of the obtained 5-nitrofluorescein in a solution of alcohol alkali with hydrazine hydrate on a nickel catalyst to obtain 5-aminofluorescein , Or by boiling in an aqueous solution of sodium sulfide. The restoration of the nitro group and the saponification of acetates in the second case occurs in one stage.
General Description
Fluoresceinamine, isomer I belongs to the class of derivatized fluoresceins.
5-Aminofluorescein Preparation Products And Raw materials
Preparation Products
Raw materials
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5-Aminofluorescein(3326-34-9)Related Product Information
- Glycine
- Fluorescein Sodium
- Fluorescein
- Fluorescein isothiocyanate
- EC 1.14.14.3
- Fluorescein diacetate
- 6-Aminocaproic acid
- ALTRENOGEST
- CHLOROPHOSPHONAZO III
- Tris(hydroxymethyl)aminomethane
- 5-(OCTADECANOYLAMINO)FLUORESCEIN
- 6-Aminofluorescein
- 5(6)-Aminofluorescein
- (hexadecanoyl)aminofluorescei
- 5-(4,6-DICHLOROTRIAZINYL)AMINOFLUORESCEIN,5-(4,6-DICHLOROTRIAZINYL)AMINOFLUORESCEIN
- 5-(N-dodecanoyl)aminofluorescein,5-(N-dodecanoyl)aminofluorescein
- AMINO ACIDS
- 5-Aminofluorescein