alpha-aMine-oMega-propionic acid hexaethylene glycol Chemical Properties

Boiling point:

481.0±45.0 °C(Predicted)

Density 

1.130±0.06 g/cm3(Predicted)

storage temp. 

-20°C

form 

solid or viscous liquid

pka

4.28±0.10(Predicted)

color 

White to Almost white

InChI

InChI=1S/C15H31NO8/c16-2-4-20-6-8-22-10-12-24-14-13-23-11-9-21-7-5-19-3-1-15(17)18/h1-14,16H2,(H,17,18)

InChIKey

PVRGRRPCHFTMMD-UHFFFAOYSA-N

SMILES

C(O)(=O)CCOCCOCCOCCOCCOCCOCCN

Safety Information

HS Code 

2942000090

alpha-aMine-oMega-propionic acid hexaethylene glycol Usage And Synthesis

Description

Amino-PEG6-acid is a PEG reagent composing one amine (NH2) and one terminal carboxylic acid group (CO2). The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with activated NHS esters to form a stable amide bond.

Uses

NH2-PEG6-CH2CH2COOH is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

IC 50

Cleavable Linker; PEGs

References

[1] Jaume Pons, et al. Engineered polypeptide conjugates and methods for making thereof using transglutaminase. US20130230543A1.

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