6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Chemical Properties

Melting point:

190-192°C

Boiling point:

468.4±45.0 °C(Predicted)

Density 

1.645±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated)

form 

Solid

pka

-0.61±0.20(Predicted)

color 

White

InChI

InChI=1S/C13H13BrClN3O/c1-7-9-6-16-13(15)17-11(9)18(12(19)10(7)14)8-4-2-3-5-8/h6,8H,2-5H2,1H3

InChIKey

HJQCAEDIUJXGCQ-UHFFFAOYSA-N

SMILES

C1(Cl)=NC=C2C(C)=C(Br)C(=O)N(C3CCCC3)C2=N1

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

RIDADR 

UN2811

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Usage And Synthesis

Use

6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.

Description

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one is a pharmaceutical intermediate that can be used to synthesize Palbociclib, an inhibitor of cyclin-dependent kinases (CDKs) 4 and 6 for the treatment of breast cancer.

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one(1016636-76-2)Related Product Information

• 6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one
• tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
• tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
• Palbociclib Impurity N
• Palbociclib Impurity D
• 5-(piperazin-1-yl)pyridin-2-aMine
• Palbociclib-012
• 5-bromo-4-chloro-N-cyclopentylpyrimidin-2-amine
• 6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one
• Ezetimibe
• (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
• 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
• pyridine-3-sulfonyl chloride
• 4-[[(4-Fluorophenyl)imino]methyl]-phenol
• Flupirtine maleate
• 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
• sacubitril
• 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-