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4SC-201

Basic information Safety Supplier Related

4SC-201 Basic information

Product Name:
4SC-201
Synonyms:
  • 4SC-201
  • RAS2410
  • ResMinostat(4SC-201)
  • ResMinostat
  • RESMINOSTAT; 4SC-201; RAS2410
  • (E)-3-[1-[[4-[(Dimethylamino)methyl]benzene]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxyacrylamide
  • ResMinostat (RAS2410)
  • (E)-3-[1-[4-[(dimethylamino)methyl]phenyl]sulfonylpyrrol-3-yl]-N-hydroxyprop-2-enamide
CAS:
864814-88-0
MF:
C16H19N3O4S
MW:
349.4
Product Categories:
  • Inhibitor
  • Inhibitors
Mol File:
864814-88-0.mol
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4SC-201 Chemical Properties

Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
8.68±0.23(Predicted)
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4SC-201 Usage And Synthesis

Uses

Resminostat is an oral histone deacetylase (HDAC) inhibitor. It inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells.

Biological Activity

resminostat, also known as ras2410, is a potent inhibitor of histone deacetylase (hdac) classes i and ii (including hdac1, hdac3 and hdac6) with 50% inhibition concentration ic50 values ranging from 43 to 72 nmol/l. resminostate has the potential to be used for the treatment of multiple myeloma (mm) due to its ability to induce histone h4 hyperacetylation, and apoptosis (ic50 ranging from 2.5 to 3 μmol/l) in mm cells. recent study results have shown that, in mm cell lines, resminostat abrogates cell growth, suppresses proliferation and induce g0/g1 cell cycle arrest as well as interfering with akt signaling pathway by decreasing phosphorylation of 4e-bp1 and p70s6k.mandl-weber s, meinel fg, jankowsky r, oduncu f, schmidmaier r, baumann p. the novel inhibitor of histone deacetylase resminostat (ras2410) inhibits proliferation and induces apoptosis in multiple myeloma (mm) cells. br j haematol. 2010; 149(4):518-528.

4SC-201Supplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 17702719238
Email
sales@sun-shinechem.com
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
ApexBio Technology LLC
Tel
+1-832-696-8203
Email
info@apexbt.com
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4SC-201(864814-88-0)Related Product Information