TAE226 (NVP-TAE226)
TAE226 (NVP-TAE226) Basic information
- Product Name:
- TAE226 (NVP-TAE226)
- Synonyms:
-
- NVP-TAE 226
- TAE226
- TAE226 (NVP-TAE226)
- 2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)-amino)pyrimidin-4-yl)amino)-N-methylbenzamide
- Benzamide, 2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-
- NVP-TAE 226 2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide
- 2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide
- TAE226 (NVP-TAE226), >98%
- CAS:
- 761437-28-9
- MF:
- C23H25ClN6O3
- MW:
- 468.94
- Product Categories:
-
- Inhibitors
- Mol File:
- 761437-28-9.mol
TAE226 (NVP-TAE226) Chemical Properties
- Density
- 1.349
- storage temp.
- Store at -20°C
- solubility
- ≥23.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 14.57±0.46(Predicted)
- color
- White to khaki
TAE226 (NVP-TAE226) Usage And Synthesis
Description
NVP-TAE226 is an inhibitor of focal adhesion kinase (FAK; IC50 = 5.5 nM) and the related proline-rich tyrosine kinase 2-β (PYK2β; IC50 = 5 nM). It can also inhibit the insulin-like growth factor 1 receptor (IC50 = 0.16 μM) as well as the activity of its downstream target genes such as MAPK and Akt. NVP-TAE226 has been shown to inhibit glioma and ovarian tumor growth in in vivo tumor models.
Uses
NVP-TAE 226 is FAK and IGF-IR inhibitor. It can be used in biological study and therapeutic use of TAE226, a bis-?anilino pyrimidine compound, inhibits the egfr-?mutant kinase including T790M mutant to show anti-?tumor effect on EGFR-?mutant non-?small cell lung cancer cells.
Definition
ChEBI: 2-[[5-chloro-2-[2-methoxy-4-(4-morpholinyl)anilino]-4-pyrimidinyl]amino]-N-methylbenzamide is a member of morpholines.
target
PYK2
References
[1]. liu, t.j., et al., inhibition of both focal adhesion kinase and insulin-like growth factor-i receptor kinase suppresses glioma proliferation in vitro and in vivo. mol cancer ther, 2007. 6(4): p. 1357-67.
[2]. plaza-menacho, i., et al., focal adhesion kinase (fak) binds ret kinase via its ferm domain, priming a direct and reciprocal ret-fak transactivation mechanism. j biol chem, 2011. 286(19): p. 17292-302.
TAE226 (NVP-TAE226)Supplier
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- 021-021-58432009 400-005-6266
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- +86 (531) 88811783
- sales@trio-pharmatech.com (International market)
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
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