(R)-2,2,2-TRIFLUORO-1-PHENYL-ETHYLAMINE Chemical Properties

Boiling point:

196.4±40.0 °C(Predicted)

Density 

1.224±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

6.15±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

Risk Statements 

34

Safety Statements 

26-36/37/39

RIDADR 

3259

(R)-2,2,2-TRIFLUORO-1-PHENYL-ETHYLAMINE Usage And Synthesis

Synthesis

General procedure for the synthesis of (R)-2,2,2-trifluoro-1-phenylethylamine from 1-phenyl-2,2,2-trifluoroethylamine: 1. Intermediate preparation: L-tartaric acid (36 g, 240.0 mmol) was added to a solution of 1-phenyl-2,2,2-trifluoroethylamine (40 g, 228.57 mmol) in isopropanol (400 mL). 2. Reaction: The reaction mixture was heated to reflux and maintained for 30 minutes. 3. Post-treatment: After completion of the reaction, the mixture was cooled to room temperature and the solid formed was collected by filtration. 4. Purification: The resulting solid was diluted with Na2CO3/H2O solution and subsequently extracted with dichloromethane (3 x 100 mL). 5. Drying and concentration: The organic phases were combined, dried over K2CO3 and subsequently concentrated under reduced pressure to afford the target product (1R)-2,2,2-trifluoro-1-phenylethylamine (12.5 g, 31% yield) as a white solid.

References

[1] Patent: WO2011/119701, 2011, A1. Location in patent: Page/Page column 40

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