Myristic Acid Alkyne Chemical Properties

Melting point:

59.1°C (estimate)

Boiling point:

384.08°C (rough estimate)

Density 

0.9192 (rough estimate)

refractive index 

1.4154 (estimate)

storage temp. 

2-8°C

solubility 

DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml

form 

Solid

pka

4.78±0.10(Predicted)

color 

Light yellow to brown

InChI

InChI=1S/C14H24O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h1H,3-13H2,(H,15,16)

InChIKey

JNXXRQLAAJXERE-UHFFFAOYSA-N

SMILES

C(O)(=O)CCCCCCCCCCCC#C

Safety Information

HS Code 

2916199590

Myristic Acid Alkyne Usage And Synthesis

Description

Alkynyl myristic acid can be used to identify and characterize the post-translational myristylated proteins with Click Chemistry.

Uses

Alkynyl myristic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Alkynyl myristic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Alkyl-Chain

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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