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Tenovin-6

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Tenovin-6 Basic information

Product Name:
Tenovin-6
Synonyms:
  • Tenovin-6
  • 4-TERT-BUTYL-N-(4-(5-(DIMETHYLAMINO)PENTANAMIDO)PHENYLCARBAMOTHIOYL)BENZAMIDE HYDROCHLORIDE
  • N-[[[4-[[5-(Dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide
  • Benzamide, N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-
  • N-[[[4-[[5-(Dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide Tenovin-6
  • Tenovin-6, 98%, SIRT inhibitor and p53 activator
  • Tenovin-6, >=98%
  • 4-(tert-Butyl)-N-((4-(4-(dimethylamino)butanamido)phenyl)carbAmothioyl)benzamide
CAS:
1011557-82-6
MF:
C25H34N4O2S
MW:
454.63
EINECS:
200-256-5
Product Categories:
  • Inhibitors
Mol File:
1011557-82-6.mol
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Tenovin-6 Chemical Properties

Density 
1.171±0.06 g/cm3(Predicted)
storage temp. 
Store at -20° C
solubility 
≥22.75 mg/mL in DMSO; insoluble in H2O; ≥2.62 mg/mL in EtOH with ultrasonic
form 
solid
pka
9.11±0.70(Predicted)
color 
White to off-white
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Safety Information

HS Code 
29242990
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Tenovin-6 Usage And Synthesis

Uses

Tenovin-6 Hydrochloride, is a small molecule activator of p53 transcriptional activity. It acts as a potent SIRT1 and SIRT2 inhibitor as well.

Definition

ChEBI: Tenovin-6 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(dimethylamino)pentanoic acid with the aromatic amino group of N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide. It has a role as an antineoplastic agent, a Sir2 inhibitor and a p53 activator. It is a monocarboxylic acid amide, a member of thioureas and a tertiary amino compound.

target

SIRT1

Tenovin-6Supplier

Dalian Meilun Biotech Co., Ltd.
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