Quinine sulfate dihydrate Chemical Properties

Melting point:

~225 °C (dec.)(lit.)

alpha 

-245 º (c=2, 0.1M HCl)

FEMA 

2977 | QUININE SULFATE

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

Soluble in a mixture of chloroform and absolute alcohol (2:1).

form 

Crystalline Powder

color 

Light yellow or beige to brown

Odor

odorless

Odor Type

odorless

Water Solubility 

0.12 g/100 mL (20 ºC)

Sensitive 

Light Sensitive

Merck 

14,8061

BRN 

6113937

Stability:

Stable. Incompatible with strong oxidizing agents, alkalies, ammonia, strong bases, iodine.

InChI

InChI=1/C20H24N2O2.H2O4S/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4)/t13-,14-,19-,20+;/s3

InChIKey

AKYHKWQPZHDOBW-QJLYHTAINA-N

SMILES

[C@H]([C@]1([H])C[C@@H]2CC[N@]1C[C@@H]2C=C)(C1=CC=NC2=CC=C(OC)C=C12)O.S(O)(O)(=O)=O |&1:0,1,4,7,9,r|

LogP

3.44

CAS DataBase Reference

6119-70-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-42/43-22-36/38

Safety Statements 

26-45-37-24-37/39

RIDADR 

UN 2811

WGK Germany 

3

RTECS 

VA8440000

F 

8

TSCA 

Yes

HS Code 

29392000

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

Quinine sulfate dihydrate Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder or fine, colourless needles.

Chemical Properties

Quinine sulfate is odorless and has a persistent, very bitter taste. It darkens on exposure to light. Its saturated solution is neutral or alkaline to litmus.

Uses

Primary alkaloid of various species of Cinchona (Rubiaceae). Optical isomer of Quinidine. Antimalarial; muscle relaxant (skeletal).

Uses

Quinine sulfate is an antimalarial agent also used as antipyreticum and in liquids (tonic etc.).

Uses

Quinine hemisulfate monohydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

brand name

Coco-Quinine (Lilly).

Synthesis

Manufacture of quinine by extraction from cinchona bark and subsequent purification and synthesis to quinine sulfate

Quinine sulfate dihydrate(6119-70-6)Related Product Information

• Sodium sulfate
• Anisole
• Aluminum sulfate
• 4-Methoxyphenylacetone
• 3-Methoxybenzaldehyde
• Ammonium sulfate
• (Trifluoromethoxy)benzene
• QUINUCLIDINE
• Quinine
• p-Anisaldehyde
• p-Anisidine
• Vanadyl sulfate
• Quinidine sulfate dihydrate
• QUINIDINE SULFATE
• Calcium phosphate
• sulfate
• QUININE SULFATE,Quinine, sulfate (2:1) (salt) (8CI)
• Cinchonidine
• Quinine Sulphate Dihydrate