Methyl 3-mercaptopropionate Chemical Properties

Melting point:

38 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))

Boiling point:

54-55 °C/14 mmHg (lit.)

Density 

1.085 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.464(lit.)

Flash point:

140 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Chloroform, Ethyl Acetate

pka

9.17±0.25(Predicted)

form 

Liquid

color 

Clear colorless

Water Solubility 

Soluble in water.

BRN 

1742952

LogP

0.870 (est)

CAS DataBase Reference

2935-90-2(CAS DataBase Reference)

NIST Chemistry Reference

Propanoic acid, 3-mercapto-, methyl ester(2935-90-2)

EPA Substance Registry System

Propanoic acid, 3-mercapto-, methyl ester (2935-90-2)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

22-23-36/37/38

Safety Statements 

45-37/39-26

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

RTECS 

UA2465980

F 

13

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29309090

Hazardous Substances Data

2935-90-2(Hazardous Substances Data)

MSDS

• Language:English Provider:3-Mercaptopropionic acid methyl ester
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Methyl 3-mercaptopropionate Usage And Synthesis

Chemical Properties

CLEAR COLORLESS LIQUID

Uses

Methyl 3-Mercaptopropionate is used in the synthesis of thioisoindolinones.

Uses

Methyl 3-mercaptopropionate is a click chemistry reagent used in the modification of oxazolines using thiol-ene click modification. It also has implications for self-assembled monolayers (SAMs). It is used in the colorimetric detection of mercury(II) in a high-salinity solution using gold nanoparticles.

Uses

The Progress in Development of Dental Restorative Materials

Application

Methyl 3-mercaptopropionate is an important chemical raw material. It is an intermediate for preparing isothiazolinone and a raw material for preparing fine chemical 4-chloro-7-methylthiophene [3,2-D ] pyrimidine. The methyl 3-mercaptopropionate is a raw material for synthesizing a simvastatin side DMB-S-MMP3- [ (2, 2-dimethyl-1-oxobutyl) sulfur ] methyl propionate serving as a blood fat-reducing drug by an enzyme method. Simvastatin is listed in the essential drug list of the World Health Organization and belongs to one of the essential drugs of the basic medical system.

Flammability and Explosibility

Non flammable

Synthesis

The traditional synthetic method of the Methyl 3-mercaptopropionate comprises the steps of adding 2% -5% of concentrated sulfuric acid as a catalyst in an inert atmosphere, refluxing (65-70 ℃) for a reaction for 15 hours, evaporating reaction liquid to remove methanol after the reaction is finished, and then deacidifying; during the deacidification process, a large amount of deionized water is added for water washing, and when the pH of the water washing solution is close to neutrality, the Methyl 3-mercaptopropionate product is obtained by reduced pressure distillation. Another method for preparing Methyl 3-mercaptopropionate is by using a reactive distillation technology. Mix the reactant 3-mercaptopropionic acid and methanol, then perform pre-reaction through a fixed bed reactor filled with a catalyst to obtain a crude product of the methyl 3-mercaptopropionate. The crude product is pumped to the middle part of the reaction rectifying tower by a feeding pump and is input; fresh methanol and a water-carrying agent are input from the lower part of the reaction rectifying tower, a catalyst is arranged at the lower part of the reaction rectifying tower, and unreacted 3-mercaptopropionic acid in the crude product continuously reacts with methanol in a catalyst bed layer of the reaction rectifying tower; after the reaction is finished, excess methanol, water carrying agent and water are extracted from the upper part of the reaction rectifying tower, and the product Methyl 3-mercaptopropionate is extracted from the bottom of the tower.

Methyl 3-mercaptopropionate(2935-90-2)Related Product Information

• Methyl acetate
• Methyl acrylate
• Calcium thioglycolate
• Acetonitrile
• Kresoxim-methyl
• Paraquat dichloride
• Basic Violet 1
• Methylparaben
• 6-Mercaptopurine
• 2-Ethylhexyl mercaptoacetate
• 2-Mercaptopropionic acid
• Mercaptoacetic acid
• ISOOCTYL 3-MERCAPTOPROPIONATE
• 2-Mercaptobenzothiazole
• POTASSIUM THIOGLYCOLATE
• 3-Mercaptopropionic acid
• Methanol
• Sodium thioglycolate