PNU 100480
PNU 100480 Basic information
- Product Name:
- PNU 100480
- Synonyms:
-
- PNU 100480
- (S)-N-[[3-[3-Fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide
- Sutezolid
- (S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
- (S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide(WXC06631)
- PF-02341272
- Sutezolid (PNU-100480, PF-02341272)
- PNU-100480; U-100480; PF-02341272
- CAS:
- 168828-58-8
- MF:
- C16H20FN3O3S
- MW:
- 353.41
- Mol File:
- 168828-58-8.mol
PNU 100480 Chemical Properties
- Melting point:
- 186-187°C
- Boiling point:
- 609.0±55.0 °C(Predicted)
- Density
- 1.321±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- pka
- 15.53±0.46(Predicted)
- color
- white to beige
- optical activity
- [α]/D -8 to -12°, c = 1 in chloroform-d
PNU 100480 Usage And Synthesis
Description
PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis. It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid , rifampin (rifampicin; ), ethambutol , and streptomycin (; MICs = ≤0.0625-0.5 mg/L). It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml). PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.
Uses
Sutezolid is an oxazolidinone antibacterial agent analog. Sutezolid is a promising antimycobacterial agent (tuberculostatic).
Biochem/physiol Actions
Sutezolid (PNU 100480) is an oxazolidinone antimicrobial. Sutezolid inhibits protein synthesis by inhibiting bacterial mRNA translation. Sutezolid is being investigated for the treatment of multiple drug–resistant and extensively drug-resistant tuberculosis. The compound is a less toxic and more potent derivative of linezolid.
PNU 100480Supplier
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- 021-61415566 800-8193336
- orderCN@merckgroup.com
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- 021-52996696,15000506266 15000506266
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- 021-65675885 18964387627
- info@efebio.com
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