3-Bromo-1,1,1-trifluoroacetone Chemical Properties

Melting point:

<-80°C

Boiling point:

87 °C/743 mmHg (lit.)

Density 

1.839 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.376(lit.)

Flash point:

41 °F

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

form 

Liquid

color 

Clear colorless to yellow

Specific Gravity

1.839

Water Solubility 

Immiscible with water.

Sensitive 

Lachrymatory

BRN 

1703387

InChIKey

ONZQYZKCUHFORE-UHFFFAOYSA-N

CAS DataBase Reference

431-35-6(CAS DataBase Reference)

NIST Chemistry Reference

1-Bromo-3,3,3-trifluoroacetone(431-35-6)

Safety Information

Hazard Codes 

F,C

Risk Statements 

11-34-37

Safety Statements 

16-26-36/37/39-45

RIDADR 

UN 2924 3/PG 2

WGK Germany 

3

F 

19

Hazard Note 

Corrosive/Flammable/Lachrymatory

HazardClass 

3

PackingGroup 

II

HS Code 

29141900

MSDS

• Language:English Provider:1-Bromo-3,3,3-trifluoroacetone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-Bromo-1,1,1-trifluoroacetone Usage And Synthesis

Chemical Properties

clear colorless to yellowish liquid

Uses

1-Bromo-3,3,3-trifluoroacetone is used in the preparation of 3-nonylthio-1,1,1-trifluoropropan-2-one and perfluoroalkylated trans-allylic alcohols. It is involved in the synthesis of cyclic tetrapeptides. Further, it reacts with potassium enolate of ethyl 4,4,4-trifluoroacetoacetate to produce ethyl 2,4-bis(trifluoromethyl)-4-hydroxydihydro-3-furoate.

Uses

3-Bromo-1,1,1-trifluoroacetone may be used in the synthesis of:

• 3-nonylthio-1,1,1-trifluoropropan-2-one
• cyclic tetrapeptides containing trifluoromethyl and pentafluoroethyl ketone as zinc binding functional group
• perfluoroalkylated trans-allylic alcohols

General Description

3-Bromo-1,1,1-trifluoroacetone reacts with potassium enolate of ethyl 4,4,4-trifluoroacetoacetate to yield ethyl 2,4-bis(trifluoromethyl)-4-hydroxydihydro-3-furoate.

3-Bromo-1,1,1-trifluoroacetone (431-35-6)Related Product Information

• (2-Bromoethyl)benzene
• 1-(4-Bromophenyl)hexane
• 1-BROMO-2-BUTYNE
• 1-BROMO-2,4-DINITROBENZENE
• 1-Bromo-5-chloropentane
• 1,1,1-Trifluoroacetone
• 1,1,3-Trichloroacetone
• BROMOACETONE
• Phosphorus oxybromide
• Triacetonamine
• Ethyl bromodifluoroacetate
• 1,1,1-Trifluoro-2,4-pentanedione
• Propiophenone
• Bromine
• 1,1-Dibromo-3,3,3-trifluoroacetone
• 3-BROMO-1,1,1-TRIFLUOROACETONE OXIME
• 3-Bromo-1,1,1-trifluoroacetone