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GUANABENZ

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GUANABENZ Basic information

Product Name:
GUANABENZ
Synonyms:
  • GUANABENZ
  • 2-[(2,6-dichlorophenyl)methylene]-hydrazinecarboximidamide
  • n-(2,6-dichlorobenzylidene)amino]guanidine
  • n-(2,6-dichlorobenzylidene)-n’-amidinohydrazine
  • nsc-68982
  • Rexitene
  • HydrazinecarboxiMidaMide, 2-[(2,6-dichlorophenyl)Methylene]-
  • 1-(2,6-DICHLOROBENZYLIDENEAMINO)GUANIDINE
CAS:
5051-62-7
MF:
C8H8Cl2N4
MW:
231.08
EINECS:
225-750-8
Mol File:
5051-62-7.mol
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GUANABENZ Chemical Properties

Melting point:
227-229° (dec)
Boiling point:
353.9±52.0 °C(Predicted)
Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 12 mg/mL (51.93 mM);Ethanol: 15 mg/mL (64.91 mM)
pka
pKa 8.1 (Uncertain)
Water Solubility 
Water: Insoluble
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22-62
Safety Statements 
22-36/37/39
RIDADR 
3249
WGK Germany 
3
HazardClass 
6.1(b)
PackingGroup 
III

MSDS

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GUANABENZ Usage And Synthesis

Description

Guanabenz is an α2-adrenergic agonist that exhibits pronounced hypotensive action, and that is associated with a reduction of overall peripheral vascular resistance, decline in frequency of cardiac contractions, and reduced cardiac output.

Originator

Wytensin,Wyeth,US,1982

Uses

alpha agonists

Uses

It is used both independently and in combination with oral diuretics for treating various degrees of hypertension.

Definition

ChEBI: Guanabenz is a dichlorobenzene.

Manufacturing Process

A mixture of 14.0 g of 2,6-dichlorobenzaldehyde, 10.8 g of aminoguanidine bicarbonate and 100 ml of pyridine was refluxed for 3 hours. The reaction mixture was poured into water and the crystalline precipitate filtered off; MP 225°C to 227°C.

Therapeutic Function

Antihypertensive

Synthesis

Guanabenz, [(2,6-dichlorobenzyliden) amino] guanidine (22.3.1), is synthesized in one step by reacting 2,6-dichlorobenzaldehyde with amino guanidine.

Purification Methods

Crystallise the guanidine from MeCN and store it in a CO2–free atmosphere. The monoHCl [23256-5-0] has m 178o(dec) [solubility w% at 25o is 1.1(H2O), 5(EtOH), 0.1(EtOAc), 0.06(CHCl3)]. It is an antihypertensive drug. [Holmes et al. Drugs 26 212 1983.]

GUANABENZSupplier

Guangdong Qianjin Chemical Reagent Co., Ltd. Gold
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0751-2818792 13435114148
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3128240096@qq.com
LGM Pharma
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1-(800)-881-8210
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inquiries@lgmpharma.com
Hangzhou Sage Chemical Co., Ltd.
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+86057186818502 13588463833
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info@sagechem.com
Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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waley188@sohu.com
Shanghai TaoSu Biochemical Technology Co., Ltd.
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021-33632979
Email
info@tsbiochem.com