1-Chloro-4-iodobenzene Chemical Properties

Melting point:

53-54 °C(lit.)

Boiling point:

226-227 °C(lit.)

Density 

1.8860

Flash point:

227 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly, Heated), Methanol (Slightly, Heated)

form 

Crystalline Powder or Crystals

color 

Off-white to light beige

Sensitive 

Light Sensitive

BRN 

1634414

InChIKey

GWQSENYKCGJTRI-UHFFFAOYSA-N

CAS DataBase Reference

637-87-6(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-chloro-4-iodo-(637-87-6)

EPA Substance Registry System

Benzene, 1-chloro-4-iodo- (637-87-6)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

36/37-24/25

WGK Germany 

3

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29039990

MSDS

• Language:English Provider:1-Chloro-4-iodobenzene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-Chloro-4-iodobenzene Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

suzuki reaction

Uses

4-Chloroiodobenzene is used as a reagent in the synthesis of Clothiapine (C588550); an atypical antipsychotic of the dibenzothiazepine chemical class that has shown efficacy in treatment-resistant schizophrenic patients.

Purification Methods

Distil it in a vacuum then recrystallise it from EtOH. [Sugden J Chem Soc 1173 1924, Beilstein 5 H 221, 5 III 579, 5 IV 695.]

1-Chloro-4-iodobenzene(637-87-6)Related Product Information

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• Iodobenzene
• Phenoxyacetyl chloride
• 2-Iodobenzoic acid
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• 1,4-Diiodobenzene
• 4-Chlorotoluene
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• (Diacetoxyiodo)benzene
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• 4-Chlorophenol
• Amlodipine Besylate
• 1-Chloro-3-nitrobenzene
• Diphenyl chlorophosphate
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• 1-CHLORO-2-IODOBENZENE,2-CHLORO-1-IODOBENZENE,1-Chloro-2-iodobenzene,99%
• 4-Chlorobenzylamine