UNBS-5162 Chemical Properties

Boiling point:

526.4±35.0 °C(Predicted)

Density 

1.389±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Soluble in DMSO

form 

crystalline solid

pka

13.50±0.20(Predicted)

color 

Light yellow to yellow

InChI

1S/C17H18N4O3/c1-20(2)6-7-21-15(22)12-5-3-4-10-8-11(19-17(18)24)9-13(14(10)12)16(21)23/h3-5,8-9H,6-7H2,1-2H3,(H3,18,19,24)

InChIKey

WCKZRLOUKYFJDY-UHFFFAOYSA-N

SMILES

[n]1([c](c2c3c([c]1=O)cccc3cc(c2)NC(=O)N)=O)CCN(C)C

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

UNBS-5162 Usage And Synthesis

Uses

UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity.

Biological Activity

UNBS5162, an amonafide (naphthalimide) derivative, is a potent antitumor agent th at inhibits tumor proliferation, progression and invasiveness. UNBS5162 is a pan-antagonist of CXCL chemokine expression. It appears th at UNBS5162 inhibits melanoma progression through inhibition of the AKT/mTOR signaling pathway.

in vivo

IC 50

CXCL

References

[1] Mijatovic T, et al. UNBS5162, a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. Neoplasia. 2008 Jun;10(6):573-86. DOI:10.1593/neo.08290
[2] Tina Mahieu, et al. UNBS5162: A novel naphthalimide derivative with potent pro-autophagic effects in human cancer cells. Cancer Research, 2007 May; 67(9) Supplement.
[3] He D, et al. UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway. Mol Med Rep. 2018 Jan;17(1):549-555. DOI:10.3892/mmr.2017.7893

UNBS-5162(956590-23-1)Related Product Information

• URMC-099
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