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2-Hydroxy-3',4'-dihydroxyacetophenone

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2-Hydroxy-3',4'-dihydroxyacetophenone Basic information

Product Name:
2-Hydroxy-3',4'-dihydroxyacetophenone
Synonyms:
  • 2-Hydroxy-3',4'-dihydroxyacetophenone
  • 3,4-dihydroxyphenyl ethanol ketone
  • 1-(3,4-Dihydroxyphenyl)-2-hydroxyethan-1-one
  • Norepinephrine Impurity 3
  • Ethanone, 1-(3,4-dihydroxyphenyl)-2-hydroxy-
  • Noradrenaline (Norepinephrine) Impurity 21
  • 1-(3,4-dihydroxyphenyl)-2-hydroxyethan-1-one, C8H8O4,Molecular Weight: 168.15
  • Norepinephrine Impurity 57
CAS:
29477-54-1
MF:
C8H8O4
MW:
168.15
Mol File:
29477-54-1.mol
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2-Hydroxy-3',4'-dihydroxyacetophenone Chemical Properties

Melting point:
195 °C(Solv: water (7732-18-5))
Boiling point:
447.0±35.0 °C(Predicted)
Density 
1.457±0.06 g/cm3(Predicted)
pka
7.66±0.20(Predicted)
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2-Hydroxy-3',4'-dihydroxyacetophenone Usage And Synthesis

Preparation

Obtained by saponification of its triacetate (SM) (m.p. 94°) with sodium hydroxide (or sodium ethoxide) in ethanol in a water bath for 20 min (33%). SM was prepared by treatment of 3,4-dihydroxy-a-chloroacetophenone with potassium acetate in refluxing acetic anhydride for 15 min (quantitative yield).

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