Thiomorpholine Chemical Properties

Melting point:

166-168

Boiling point:

169 °C (lit.)

Density 

1.026 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.538(lit.)

Flash point:

140 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

organic solvents: miscible(lit.)

form 

clear liquid

pka

9.14±0.20(Predicted)

color 

Colorless to Light yellow to Light orange

Water Solubility 

Miscible with waterMiscible with water and organic solvents.

Sensitive 

Air Sensitive

Merck 

14,9300

BRN 

102550

InChIKey

BRNULMACUQOKMR-UHFFFAOYSA-N

CAS DataBase Reference

123-90-0(CAS DataBase Reference)

NIST Chemistry Reference

Thiomorpholine(123-90-0)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-37-36/37/38-R37-R34

Safety Statements 

26-36/37/39-45-36-S45-S36/37/39-S26

RIDADR 

UN 3267 8/PG 3

WGK Germany 

3

F 

10-13-23

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

III

HS Code 

29349990

MSDS

• Language:English Provider:Thiomorpholine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Thiomorpholine Usage And Synthesis

Chemical Properties

Clear colorless to yellow liquid

Uses

Organic synthesis.

Uses

Thiomorpholine is used as an intermediate for blonanserin. It is used in the preparation of pyrrole derivatives, which acts as a antimycobacterial agent. It is further involved in the hypocholesterolemic activity.

Definition

ChEBI: A saturated organic heteromonocyclic parent that is an analogue of morpholine where the oxygen atom is replaced by sulfur.

General Description

Thiomorpholine forms complexes with Cu(II), Pt(II) and Ni(II) salts and their catalytic activity has been investigated.

Purification Methods

Purify it by vacuum distillation. The hydrochloride has m 179o (from isoPrOH or EtOH/Et2O/HCl). [Davies J Chem Soc 306 1920, Beilstein 27 II 4, 2 III/IV 636.]

Thiomorpholine(123-90-0)Related Product Information

• Tridemorph
• Dimethomorph
• Moroxydine
• Moroxydine hydrochloride
• 1,1-DIOXIDE-4-THIOMORPHOLINE,THIOMORPHOLINE DIOXIDE
• ThioMorpholine-1-oxide HCl
• thiomorpholin-3-one
• THIOMORPHOLINE 1,1-DIOXIDE HYDROCHLORIDE
• Thiomorpholine, 4-methyl-, 1,1-dioxide,thiomorpholine,4-methyl-,1,1-dioxid
• 4-(Prop-2-yn-1-yl)thiomorpholine 1,1-dioxide
• 1,1-DIOXIDE-4-(PHENYLMETHYL) THIOMORPHOLINE
• THIOMORPHOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• N-(3-DYDROXYPROPYL)THIOMORPHOLINE 1,1-DIXOXIDE
• THIOMORPHOLINE-3-CARBOXYLIC ACID
• THIOMORPHOLINE, 4-(3-AMINOROPYL)-1,1-DIOXIDE,THIOMORPHOLINE, 4-(3-AMINOPROPYL)-1,1-DIOXIDE
• 1-(2-Aminoethyl)thiomorpholine
• 4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE
• 4-ALLYL-1LAMBDA6,4-THIAZINANE-1,1-DIONE