SiraMesine, Lu-28-179 CAS#: 224177-60-0

SiraMesine, Lu-28-179 Basic information

Product Name:

SiraMesine, Lu-28-179

Synonyms:

SiraMesine, Lu-28-179
SiraMesine (hydrochloride)
1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine] monohydrochloride
Siramesine hydrochloride, >=98%
Siramesine (HCl salt), Lu-28-179
Siramesine hydrochloride 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine] monohydrochloride
SiraMesine, Lu-28-179 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine] monohydrochloride
SiramesineLu-28-179 hydrochloride

CAS:

224177-60-0

MF:

C30H32ClFN2O

MW:

491.0392832

Product Categories:

Inhibitors

Mol File:

224177-60-0.mol

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SiraMesine, Lu-28-179 Chemical Properties

Melting point:: 225 °C
storage temp.: Sealed in dry,Room Temperature
solubility: >49.1mg/mL in DMSO
form: powder to crystal
color: White to Light yellow

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Safety Information

HS Code: 2934.99.4700

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SiraMesine, Lu-28-179 Usage And Synthesis

Uses

Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12?nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17?nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3].

IC 50

Sigma 1 Receptor

storage

Store at -20°C

SiraMesine, Lu-28-179Supplier

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