Methyl 4-aminobenzoate Chemical Properties

Melting point:

110-111 °C (lit.)

Boiling point:

273.17°C (rough estimate)

Density 

1.2023 (rough estimate)

refractive index 

1.5810 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

3.82g/l

form 

Crystals or Crystalline Powder

pka

pK1:2.38(＋1) (25°C)

color 

White to beige

Water Solubility 

Soluble in alcohol and ether. Slightly soluble in water.

BRN 

775913

InChIKey

LZXXNPOYQCLXRS-UHFFFAOYSA-N

LogP

1.370

CAS DataBase Reference

619-45-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzoic acid, 4-amino-, methyl ester(619-45-4)

EPA Substance Registry System

Benzoic acid, 4-amino-, methyl ester (619-45-4)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-37/39-36/37/39

WGK Germany 

3

RTECS 

DG2900000

TSCA 

Yes

HS Code 

29224995

MSDS

• Language:English Provider:4-Aminobenzoic acid methyl ester
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Methyl 4-aminobenzoate Usage And Synthesis

Chemical Properties

white to beige crystals or crystalline powder

Uses

Methyl 4-aminobenzoate is used in the synthesis of guanidine alkaloids, (±)-martinelline and (±)-martinellic acid by a protic acid catalyzed hetero Diels-Alder coupling reaction with N-Cbz 2-pyrroline. It is also used in organic synthesis and acts as a dye intermediate. Further, it is used to prepare 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid methyl ester by reacting with 2-acetylamino-benzoic acid.

Uses

Methyl 4-aminobenzoate was used in the syntheses of guanidine alkaloids, (±)-martinelline and (±)-martinellic acid by a protic acid catalyzed hetero Diels-Alder coupling reaction with N-Cbz 2-pyrroline.

Synthesis Reference(s)

Synthetic Communications, 26, p. 973, 1996 DOI: 10.1080/00397919608003701
Synthesis, p. 23, 1978

General Description

The catalytic oxidation of methyl 4-aminobenzoate by hydrogen peroxide was studied.

Methyl 4-aminobenzoate(619-45-4)Related Product Information

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