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17- Phenyl Trinor Prostaglandin F2α Methyl Amide

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17- Phenyl Trinor Prostaglandin F2α Methyl Amide Basic information

Product Name:
17- Phenyl Trinor Prostaglandin F2α Methyl Amide
Synonyms:
  • 17- Phenyl Trinor Prostaglandin F2α Methyl Amide
  • 17-phenyl trinor Prostaglandin F2.alpha. methyl amide
  • Bimatoprost Impurity 5
  • (~{Z})-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-methylhept-5-enamide
  • 17- Phenyl Trinor Prostaglandin F2α Methyl Amide (10mg/mL in Ethanol)
  • 5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-methyl-, (5Z)-
  • Bimatoprost Impurity E
  • Bimatoprost Methyl Amide
CAS:
155206-01-2
MF:
C24H35NO4
MW:
401.54
Mol File:
155206-01-2.mol
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17- Phenyl Trinor Prostaglandin F2α Methyl Amide Chemical Properties

Boiling point:
621.5±55.0 °C(Predicted)
Density 
1.159±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Ethanol
form 
Clear Colourless Solution
pka
14.25±0.20(Predicted)
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17- Phenyl Trinor Prostaglandin F2α Methyl Amide Usage And Synthesis

Description

17-phenyl trinor Prostaglandin F (17-phenyl trinor PGF) is a metabolically stable analog of PGF and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF. The ethyl amide of 17-phenyl trinor PGF bimatoprost has been approved for use as an ocular hypotensive drug. 17-phenyl trinor PGF methyl amide is an analog of bimatoprost. Its biological and toxicological properties have not been evaluated.

Uses

17-Phenyl Trinor Prostaglandin F2α-Methyl Amide is a stable analog of PGF2α and is a potent agonist of for the FP receptor. Analog of Bimatoprost (B386800), an antiglaucoma agent.

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