MM-102
MM-102 Basic information
- Product Name:
- MM-102
- Synonyms:
-
- CS-2007
- HMTASE INHIBITOR IX;MM102;MM 102;MM-102
- MM-102
- Cyclopentanecarboxamide, 1-[[(2S)-5-[(aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-
- HMTase Inhibitor IX
- 1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]cyclopentanecarboxamide]
- MM-102 TFA Salt
- MM-102 USP/EP/BP
- CAS:
- 1417329-24-8
- MF:
- C35H49F2N7O4
- MW:
- 669.8
- Product Categories:
-
- Inhibitors
- Mol File:
- 1417329-24-8.mol
MM-102 Chemical Properties
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20° C
- solubility
- insoluble in H2O; ≥22.6 mg/mL in EtOH; ≥67 mg/mL in DMSO
- form
- Powder
- pka
- 12.90±0.20(Predicted)
- color
- White to off-white
MM-102 Usage And Synthesis
Uses
MM-102 is a small molecule WDR5/MLL1 protein-protein interaction inhibitor. MM-102 in bone marrow cells transduced with MLL1-AF9 fusion construct decreases the expression of HoxA9 and Meis-1, two critical MLL1 target genes in MLL1 fusion protein mediated leukemogenesis.
Biological Activity
mm-102 is an antagonist of mll1 with ic50 value of 2.4nm [1].mixed lineage leukemia 1 (mll1) is a histone h3 lysine 4 (h3k4) methyltransferase. the interaction of mll1 and wdr5 is essential for mll1 enzymatic activity and is a target for the treatment of acute leukemia. mm-102 is a peptidomimetic of mll1. it has a high binding affinity to wdr5 with ic50 value of 2.4nm [1].mm-102 is reported to reduce the expression of mll1 targeted genes hoxa9 and meis-1 in mll1-af9 transduced murine cells. since these two genes are required for mll1 mediated leukemogenesis, mm-102 is found to inhibit cell growth of leukemia cells harboring mll1 fusion proteins. it dose-dependently inhibits the cell growth in the mv4;11 and kopn8 cell lines with ic50 values both of 25μm[1].
target
MLL1
References
[1] karatas h, townsend ec, cao f, chen y, bernard d, liu l, lei m, dou y, wang s. high-affinity, small-molecule peptidomimetic inhibitors of mll1/wdr5 protein-protein interaction. j am chem soc. 2013 jan 16;135(2):669-82.
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