beta-Cyclodextrin hydrate Chemical Properties

Melting point:

>260 °C (dec.)(lit.)

alpha 

161 º (c=1, H2O 25 ºC)

storage temp. 

Refrigerator

solubility 

Water (Slightly)

form 

Crystalline Powder

color 

White

optical activity

[α]20/D +142°, c = 1 in H2O (Dry basis)

Water Solubility 

18.5 g/L (25 ºC)

Merck 

14,2718

BRN 

5915513

Safety Information

Safety Statements 

24/25

WGK Germany 

2

RTECS 

GU2293000

TSCA 

Yes

HS Code 

35051000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

beta-Cyclodextrin hydrate Usage And Synthesis

Description

β-Cyclodextrin (β-CD) is a cyclic oligosaccharide that contains seven D-(+)-glucopyranose units and has been used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH₂ groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility.

Chemical Properties

white crystalline powder

Uses

beta-Cyclodextrin hydrate forms clathrates. Produces a water-soluble complex with dansyl chloride for the fluorescent labeling of proteins. It is used in pharmaceutical research, as pharmaceutical intermediates and also as chemical reagents.

General Description

β-cyclodextrin (β-CD), a well-known macrocyclic oligosaccharide member of the CD family, is composed of seven D-glucose units connected via α(1→4) glycosidic bonds. Its ability to form several inclusion complexes with organic as well as inorganic compounds makes it a potential candidate in solid and solution state determinations.

Purification Methods

Recrystallise β-cyclodextrin from water and dry it for 12hours in a vacuum at 110o, or 24hours in a vacuum at 70o. The purity is assessed by TLC on cellulose containing a fluorescent indicator. [Taguchi, J Am Chem Soc 108 2705 1986, Tabushi et al. J Am Chem Soc 108 4514 1986, Orstam & Ross J Phys Chem 91 2739 1987.] [Beilstein 19 IV 6287, 19/12 V 801.]

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