FADROZOLE
FADROZOLE Basic information
- Product Name:
- FADROZOLE
- Synonyms:
-
- FADROZOLE
- 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridine-5-yl)benzonitrile
- 4-[(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin)-5-yl]benzonitrile
- 4-[[5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin]-5-yl]benzonitrile
- 5,6,7,8-Tetrahydro-5-(4-cyanophenyl)imidazo[1,5-a]pyridine
- CGS-16949
- Fadrozole Hydrochloride Hydrate
- Afema
- CAS:
- 102676-47-1
- MF:
- C14H13N3
- MW:
- 223.27
- Mol File:
- 102676-47-1.mol
FADROZOLE Chemical Properties
- Melting point:
- 0°C
- Boiling point:
- 0°C
- Density
- 1.20
- Flash point:
- 0°C
- storage temp.
- 2-8°C
- solubility
- DMSO : ≥ 100 mg/mL (447.89 mM)
- form
- Solid
- pka
- 7.16±0.40(Predicted)
- color
- White to off-white
- EPA Substance Registry System
- Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)- (102676-47-1)
FADROZOLE Usage And Synthesis
Uses
Antineoplastic
Definition
ChEBI: 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile is an imidazopyridine.
in vivo
Fadrozole hydrochloride is able to inhibit the aromatase-mediated androstenedione-induced uterine hypertrophy in immature female rats with an ED50 of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED50 of 30 mg/kg when given orally[1]. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars dta mas in female rats, and reduces the of spontaneous hcu ar tumours in male and female rats[2]. Administration of fadrozole in male and female mice suppresses the production of 17b-estradiol, accompanied with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole treatment returns these levels to baseline values[3].
IC 50
Aromatase
FADROZOLE Preparation Products And Raw materials
Raw materials
FADROZOLESupplier
- Tel
- 0571-82693216
- info@yuhaochemical.com
- Tel
- 027-88320699
- tycshyy@126.com
- Tel
- 021-58955995
- sales@medchemexpress.cn
- Tel
- +1 (866) 930-6790
- info@adooq.com
- Tel
- 021-33632979
- info@tsbiochem.com