1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione Chemical Properties

Melting point:

132-135 °C

Density 

1.572±0.06 g/cm3(Predicted)

pka

9.39±0.10(Predicted)

1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione Usage And Synthesis

Uses

1-β-D-Arabinofuranosyluracil-2-C-methyl is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione(114262-49-6)Related Product Information

• Sofosbuvir
• SofosBuvir Impurity 14
• SofosBuvir Impurity 52
• PSI-7976
• 2'-deoxy-2'-fluoro-2'-C-methyluridine
• SofosBuvir Impurity 50
• (S)-methyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
• Sofosbuvir Impurity23
• Sofosbuvir impurity I
• Sofosbuvir IMpurity C 1337482-15-1
• SofosBuvir Impurity 39
• 1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
• sofosBuvir impurity 1
• Sofosbuvir Impurity25
• Sofosbuvir Impurity 5
• Sofosbuvir metabolites
• D-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester
• SofosBuvir impurity 44