tert-Butyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)carbamate Chemical Properties

Boiling point:

489.1±45.0 °C(Predicted)

Density 

1.134±0.06 g/cm3(Predicted)

pka

10.92±0.46(Predicted)

tert-Butyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)carbamate Usage And Synthesis

Uses

Tert-Butyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)carbamate is a Vilanterol impurity. Vilanterol is a novel and selective agonist of β2-ar.

Synthesis

Trifluoroacetic acid (10.2 mL) was added to di-(tert-butyl)2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl) -2-oxoethyliminodicarbonic acid at 20°C (46.37 g) in a stirred solution of dichloromethane (500 mL) and stirred for 4 hours. Aqueous sodium hydroxide solution (0.5 M, 400 mL) was added to the reaction solution, stirred for half an hour, and separated. The organic layer was washed with water (500 mL), dried, concentrated, and recrystallized from ether to obtain tert-Butyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)carbamate 15.15g, yield 43 %.

tert-Butyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)carbamate(452339-71-8)Related Product Information

• (R)-2-Amino-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol
• A-1-(AMINOMETHYL)-4-HYDROXY-1,3-BENZENDIMETHANOL
• Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-
• Ethanol, 2-[(2,6-dichlorophenyl)Methoxy]-
• Benzene, 2-[[2-[(6-broMohexyl)oxy]ethoxy]Methyl]-1,3-dichloro
• 21ξ-morpholino-23,24-dinor-chola-4,20-dien-3-one
• Androstenone hydrazone
• 17-Iodoandrosta-5,16-dien-3beta-ol
• BISNORCHOLENALDEHYDE
• CarbaMic acid, [(2R)-2-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester
• 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-
• N-(1-Cyclohexen-1-yl)morpholine
• Vilanterol Impurity 45
• Vilanterol Impurity 25
• di-(tert-butyl)2-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-2-oxoethyliMinodicarbonate
• Vilanterol Impurity 10
• Vilanterol Impurity 14
• Vilanterol Impurity 11