AP-761
AP-761 Basic information
- Product Name:
- AP-761
- Synonyms:
-
- AP-761
- 5-Pyrimidineacetic acid, 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]-
- BI671800
- BI671800;AP-761;AP761;AP 761
- BI 671800 (BI671800)
- AP-761 / BI671800
- BI-67180
- BI-671800,BI671800,Inhibitor,BI 671800,Prostaglandin Receptor,inhibit
- CAS:
- 1093108-50-9
- MF:
- C25H26F3N5O3
- MW:
- 501.5
- Product Categories:
-
- AP-761
- Mol File:
- 1093108-50-9.mol
More
Less
AP-761 Chemical Properties
- Boiling point:
- 611.4±55.0 °C(Predicted)
- Density
- 1.351±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO: soluble
- form
- A crystalline solid
- pka
- 3.20±0.10(Predicted)
- color
- White to off-white
More
Less
AP-761 Usage And Synthesis
Uses
BI-671800 is a selective and potent CRTH2 antagonist.
in vivo
BI-671800 (compound A, 0.1-10 mg/kg, i.g.) shows significant inhibition of AHR in mice[1].
BI-671800 (compound A), effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals[3].
| Animal Model: | 6-8-week-old age- and sex-matched BALB/c mice (mice were sensitized for 14 days, challenged intranasally)[1]. |
| Dosage: | 10-0.1 mg/kg |
| Administration: | Oral gavage for 4 weeks |
| Result: | Shows significant inhibition of AHR in mice. |
IC 50
hCRTH2: 4.5 nM (IC50); mCRTH2: 3.7 μM (IC50)
AP-761Supplier
BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
Taizhou Tongxin Bio-Tech Co., Ltd
- Tel
- 0523-86818997 18652728585
- sales@allyrise.com
Bide Pharmatech Ltd.
- Tel
- 400-400-164-7117 18317119277
- product02@bidepharm.com
Shanghaizehan biopharma technology co., Ltd.
- Tel
- 021-61350663 13052117465
- sales@zehanbiopharma.com
Taizhou Ruixin Chemical Co., Ltd.
- Tel
- 0576-89085261 15867635987
- jasonhu09@163.com