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Mosapride

Basic information Safety Supplier Related

Mosapride Basic information

Product Name:
Mosapride
Synonyms:
  • 4-AMINO-5-CHLORO-2-ETHOXY-N-((4-(4-FLUOROBENZYL)-2-MORPHOLINYL)METHYL)BENZAMIDE
  • 4-AMINO-5-CHLORO-2-ETHOXY-N-[4-(4-FLUORO-BENZYL)-MORPHOLIN-2-YLMETHYL]-BENZAMIDE
  • 4-AMINO-5-CHLORO-2-ETHOXY-N-[[[4-(4-FLUOROPHENYL)METHYL]-2-MORPHOLINYL]METHYL]-BENZAMIDE
  • ((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide/mosapride
  • 4-Amino-5-Chloro-2-Ethoxy-N-((4-(4-Fluorobenzyl)-2-Morpholinyl)Methyl)Benzamide/Mosapride
  • MOSAPRIDE
  • Mosapride reference
  • Mosapride/4-Amino-5-Chloro-2-Ethoxy-N-((4-(4-Fluorobenzyl)-2-Morpholinyl)Methyl)Benzamide
CAS:
112885-41-3
MF:
C21H25ClFN3O3
MW:
421.89
Product Categories:
  • API
  • TAK-370, AS-4370, Gasmotin
  • Agonist
  • Pharmaceutical Intermediates
  • Amines
  • Aromatics
  • Agro Products
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
112885-41-3.mol
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Mosapride Chemical Properties

Melting point:
151-153°C
Boiling point:
549.2±50.0 °C(Predicted)
Density 
1.272±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
13.52±0.46(Predicted)
color 
White to Off-White
CAS DataBase Reference
112885-41-3(CAS DataBase Reference)
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Mosapride Usage And Synthesis

Description

Mosapride citrate, a new gastroprokinetic benzamide was introduced in Japan as Gasmotin for the relief of gastrointestinal symptoms in patients with chronic gastritis, gastro-oesophageal reflux, dyspepsia and post-surgery use. Mosapride is synthesized by final amidation between the corresponding benzoic acid, itself obtained in 3 steps from methyl 4-acetamido salicylate, and the appropriate 2-aminomethyl-morpholine. Mosapride is a 5-HT4 partial agonist without notable activity for D2, 5-HT1 , 5-HT2, alpha-1 and alpha-2 receptors. In dogs, mosapride was as potent as cisapride to stimulate antral and duodenal motility. In most of species including man, mosapride undergoes extensive cleavage to a N-debenzylated metabolite which retains partial 5-HT4 activity but has potent 5-HT3 antagonist activity.

Chemical Properties

White to Off-White Crystalline Solid

Originator

Dainippon (Japan)

Uses

A selective 5-HT4 receptor agonist. Gastroprokinetic.

Uses

gastroprokinetic agent

Definition

ChEBI: Mosapride is a racemate comprising equimolar amounts of (R)- and (S)-mosapride. It is a gastroprokinetic agent which acts on 5-hydroxytryptamine type 4 (5-HT4) receptors in the gastrointestinal plexus, consequently increasing the release of acetylcholine and hence enhancing gastrointestinal motility and gastric emptying. It has a role as a gastrointestinal drug and a serotonergic agonist. It contains a (R)-mosapride and a (S)-mosapride.

brand name

Gasmotin

Hazard

A poison by ingestion.

Safety Profile

A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx, F-, and Cl-.

MosaprideSupplier

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